Evidence map›Paper›PMID 41213700›Full record

ArticleBMJ open2025

Associations of arterial stiffness onset age with type 2 diabetes risk: a large-scale Chinese cohort study.

Fei Li, Yalan Li, Xiaoxiao Zhong, Jie Wang, Rujia Miao, Ting Chen, Yuan Hong, Liyong Zhu, Yao Lu

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Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fei Li *Clinical Research Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yalan Li *Clinical Research Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiaoxiao Zhong *Clinical Research Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jie WangClinical Research Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Rujia MiaoClinical Research Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ting ChenZhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0000-0002-9723-9020
Yuan HongClinical Research Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Liyong ZhuDepartment of Metabolic and Bariatric Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China luyao0719@csu.edu.cn zly8128@csu.edu.cn.ORCID http://orcid.org/0000-0002-4666-8458
Yao LuClinical Research Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China luyao0719@csu.edu.cn zly8128@csu.edu.cn.ORCID http://orcid.org/0000-0001-6743-7870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the associations between arterial stiffness (AS) onset age and type 2 diabetes mellitus (T2DM) risk.

designLarge-scale cohort study.

settingThe largest medical centre in central China.

participantsThis study enrolled 22 588 participants free of T2DM at baseline. All participants took an annual physical examination from 2012 to 2016, with fasting blood glucose and brachial-ankle pulse wave velocity measurements. PRIMARY AND SECONDARY OUTCOME MEASURES: Cox proportional model was used to investigate the association between AS onset age and T2DM risk. Sex-specific analysis was also performed, and the association between early vascular ageing (EVA), normal vascular ageing (NVA), supernormal vascular ageing (SUPERNOVA) onset age and diabetes risk was also examined.

resultsA total of 757 (3.4%) participants were diagnosed with T2DM. Compared with participants free of AS in each specific age group, the earlier AS onset age was more strongly associated with T2DM risk, especially for middle age, with the fully adjusted hazard risk (HR) and 95% CI of 4.63 (2.79-7.67) for AS onset age at 50. Similar results were observed both in males and females, with the fully adjusted HR and 95% CI of 4.54 (2.60 to 7.93) for males and 4.86 (1.48 to 16.01) for females, with AS onset age at 50. Such an association was also observed in the exploration of EVA, NVA and SUPERNOVA onset age and incident T2DM risk.

conclusionThis study revealed that the middle-aged onset of AS was more significantly associated with a higher T2DM risk. Early screening of AS, especially in middle age, may assist in T2DM detection and postpone diabetic vascular complications.

Indexed as

Diabetes Mellitus, Type 2Vascular StiffnessAdultAgedAge of OnsetAnkle Brachial IndexBlood GlucoseChinaCohort StudiesEast Asian PeopleFemaleHumansMaleMiddle AgedProportional Hazards ModelsPulse Wave AnalysisBlood GlucoseCardiovascular DiseaseDiabetes Mellitus, Type 2Observational StudyVASCULAR MEDICINE

Identifiers

PMID41213700
PMCPMC12598970

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.