ArticleAJNR. American journal of neuroradiology2026
Hippocampal Subfield Susceptibility Alterations in Mild Cognitive Impairment Revealed by 7T MRI.
Article in AJNR. American journal of neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background and purposeHippocampal magnetic susceptibility alterations may serve as early neurodegenerative biomarkers of Alzheimer disease (AD), but subfield-level evidence in mild cognitive impairment (MCI) remains limited. This study uses submillimeter high-resolution quantitative susceptibility mapping (QSM) to investigate hippocampal subfield susceptibility changes in MCI. MATERIALS AND
methodsThirteen individuals with MCI and 13 cognitively normal controls (NC) underwent 7T MRI scans including MP2RAGE and multiecho gradient echo imaging (for QSM). The visibility of hippocampal strata radiatum, lacunosum, and moleculare (SRLM) was assessed using a visual rating scale. Hippocampal subfields (Cornu Ammonis 1 [CA1], CA2, CA3, dentate gyrus [DG], and subiculums) were segmented, and magnetic susceptibility values (χ) were extracted for each subfield. The susceptibility difference between the DG and other subfields was also calculated. Associations between subfield susceptibility measures and cognitive performance were then assessed.
resultsQualitative analysis revealed a distinct hyperintense curved pattern in the hippocampus on the 7T QSM image, corresponding to the SRLM. In NC, this pattern was clearly visible exhibiting consistently delineated boundaries, while it appeared blurred or absent in most subjects with MCI. The visual rating results showed that NC had significantly higher scores than subjects with MCI (Hedgesg = 1.43, 95% confidence interval) [95% CI, 0.60-2.35;
conclusions7T QSM reveals susceptibility changes in hippocampal substructures in individuals with MCI, providing a potential early biomarker for AD.
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