Evidence map›Paper›PMID 41213901›Full record

ArticleNature communications2025

DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans.

Cristian Ricaurte-Perez, Joshua P Gill, P Kerr Wall, Olga Dubuisson, Kathryn R DeLeo, K Adam Bohnert, Alyssa E Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Autophagy: A Double-Edged Sword in the Aging ofInternational journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Cristian Ricaurte-PerezLouisiana State University, Department of Biological Sciences, Baton Rouge, LA, USA.
Joshua P GillLouisiana State University, Department of Biological Sciences, Baton Rouge, LA, USA.
P Kerr WallLouisiana State University, Department of Biological Sciences, Baton Rouge, LA, USA.
Olga DubuissonLouisiana State University, Department of Biological Sciences, Baton Rouge, LA, USA.
Kathryn R DeLeoLouisiana State University, Department of Biological Sciences, Baton Rouge, LA, USA.
K Adam BohnertLouisiana State University, Department of Biological Sciences, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-2590-460X
Alyssa E JohnsonLouisiana State University, Department of Biological Sciences, Baton Rouge, LA, USA. johnsona@lsu.edu.ORCID http://orcid.org/0000-0002-9356-2808

Funding

Pexophagy regulation in live animals and its role in aging and longevityR01AG079970 · NIA · LOUISIANA STATE UNIV A&M COL BATON ROUGE · 2024 to 2025
$590k
NIA NIH HHS R01 AG079970NIGMS NIH HHS R35 GM138116U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM138116U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG079970
6 · The paper itself

Abstract

Transcription factors DAF-16/FOXO and HLH-30/TFEB have been linked to aging regulation, but how they synergize to promote longevity is not fully understood. Here, we reveal a functional interaction between these two transcription factors that supports healthier aging in Caenorhabditis elegans. Namely, DAF-16 and HLH-30 cooperate to trigger robust lysosomal tubulation under various contexts, which contributes to systemic health benefits in late age. Remarkably, lysosome tubulation can be artificially induced via overexpression of a small lysosomal gene, dSVIP, in the absence of one transcription factor, but not both. Mechanistically, intestinal overexpression of dSVIP leads to nuclear accumulation of DAF-16 and HLH-30 in gut and non-gut tissues and triggers global gene expression changes, including induction of vps-34 and related lipid-metabolism genes, that promote tubular-lysosome activity. Collectively, our work reveals a cellular process under control of DAF-16 and HLH-30 that elicits pro-health effects in aging.

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsCaenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsLysosomesAgingAnimalsBasic Helix-Loop-Helix ProteinsGene Expression RegulationLongevityBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans Proteinsdaf-16 protein, C elegansForkhead Transcription FactorsHLH-30 protein, C elegans

Identifiers

PMID41213901
PMCPMC12603087

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.