Evidence map›Paper›PMID 41214113›Full record

ArticleScientific reports2025

Consumption of ultraprocessed foods and breast density in adolescence.

Angela Devoto, María Luisa Garmendia, Marcela Jacard, Ana Pereira

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Angela DevotoInstitute of Nutrition and Food Technology, University of Chile, Avda. El Libano 5524, 7830490, Macul, Santiago, Chile.
María Luisa GarmendiaInstitute of Nutrition and Food Technology, University of Chile, Avda. El Libano 5524, 7830490, Macul, Santiago, Chile.
Marcela JacardDepartment of Digital Health, Ministry of Health, Santiago, Chile.
Ana PereiraInstitute of Nutrition and Food Technology, University of Chile, Avda. El Libano 5524, 7830490, Macul, Santiago, Chile. apereira@inta.uchile.cl.

Funding

American Institute of Cancer Research 961157National Fund for Scientific and Technological Development from the Government of Chile (FONDECYT) 1230813
6 · The paper itself

Abstract

Breast density (BD) is one of the major risk factors for breast cancer (BC) and has the potential to be used as an early marker. Puberty is a critical period for carcinogenesis, and identifying events that modify BD during this stage could aid in understanding future BC risk. The consumption of ultra-processed foods (UPFs) has been associated with BC; however, evidence of their effect on BD, particularly in adolescents, is lacking. To assess the association between the intake of UPFs during the peripubertal period and BD measured at 4 years after menarche onset, absolute fibroglandular volume (AFGV) and the percentage of fibroglandular volume (%FGV) were used. The Growth and Obesity Cohort Study is a longitudinal study of 550 girls recruited in 2006 at daycare centers in the southeastern area of Santiago, Chile. We measured the %FGV and AFGV via dual-energy X-ray absorptiometry (DXA) 4 years after menarche. Girls had at least one 24-h dietary recall survey (R24H) during the peripubertal period. Simple and multiple linear regression models were used to evaluate the associations between UPF consumption (calories and grams, categorized in quartiles according to the sample distribution) and BD outcomes, adjusting for confounders such as birth weight, body mass index, tobacco use, physical activity, menstrual cycle stage, maternal education, age at menarche, total energy consumption, and maternal BD. Data from 330 girls revealed an average daily intake of 1849 kcal (41.67% from UPFs). No consistent associations were observed between UPF intake and %FGV and AFGV.]. Stratification by menstrual cycle phase revealed a significant increase in %FGV and AFGV for Q2 vs. Q1 UPF intake as a percentage of grams in the follicular stage [β: 0.12; 95% CI 0.01, 0.22 and β: 0.25; 95% CI 0.07, 0.43, respectively]. UPF consumption during puberty showed no consistent association with BD, except in girls whose UPF consumption was measured during the follicular phase. Further studies are needed to confirm these findings and understand the effects of food processing on BD.

Indexed as

BreastBreast DensityDietFast FoodsAdolescentBreast NeoplasmsChildFemaleHumansLongitudinal StudiesMenarcheRisk FactorsAdolescentsBreast cancerBreast densityUltra-processed foods

Identifiers

PMID41214113
PMCPMC12603022

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.