Evidence map›Paper›PMID 41214166›Full record

ArticleScientific reports2025

Comparative analysis of targeted metabolomic profiles reveals plasma metabolite differences across three Italian heavy pig breeds.

Samuele Bovo, Matteo Bolner, Giuseppina Schiavo, Flaminia Fanelli, Giuliano Galimberti, Francesca Bertolini, Anisa Ribani, Stefania Dall'Olio, Paolo Zambonelli, Uberto Pagotto and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Samuele BovoAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Giuseppe Fanin 46, Bologna, 40127, Italy.
Matteo BolnerAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Giuseppe Fanin 46, Bologna, 40127, Italy.
Giuseppina SchiavoAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Giuseppe Fanin 46, Bologna, 40127, Italy.
Flaminia FanelliDepartment of Surgical and Medical Sciences, Endocrinology Unit, University of Bologna, Via Giuseppe Massarenti 9, Bologna, 40138, Italy.
Giuliano GalimbertiDepartment of Statistical Sciences "Paolo Fortunati", University of Bologna, Via delle Belle Arti 41, Bologna, 40126, Italy.
Francesca BertoliniAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Giuseppe Fanin 46, Bologna, 40127, Italy.
Anisa RibaniAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Giuseppe Fanin 46, Bologna, 40127, Italy.
Stefania Dall'OlioAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Giuseppe Fanin 46, Bologna, 40127, Italy.
Paolo ZambonelliAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Giuseppe Fanin 46, Bologna, 40127, Italy.
Uberto PagottoDepartment of Surgical and Medical Sciences, Endocrinology Unit, University of Bologna, Via Giuseppe Massarenti 9, Bologna, 40138, Italy.
Luca FontanesiAnimal and Food Genomics Group, Division of Animal Sciences, Department of Agricultural and Food Sciences, University of Bologna, Viale Giuseppe Fanin 46, Bologna, 40127, Italy. luca.fontanesi@unibo.it.

Funding

HORIZON EUROPE Food, Bioeconomy, Natural Resources, Agriculture and Environment Re-Livestock - Grant agreement ID: 101059609Ministero dell'Università e della Ricerca PRIN2017 PigPhenomicsNextGenerationEU Agritech National Research Center (Agritech Spoke 1)NextGenerationEU PRIN2022 HamCaptureNextGenerationEU PRIN2022 PNRR FEEDTHEPIG
6 · The paper itself

Abstract

In livestock, many economically important traits vary among breeds and lines, reflecting the influence of different genetic backgrounds on trait expression. In this study, we assessed how molecular phenotypes vary among three heavy pig breeds, by analysing the level of more than 180 plasma metabolites using a targeted metabolomic platform. Plasma was from 12 Italian Large White, 12 Italian Duroc and 12 Italian Landrace pigs, raised and fed in the same way. Advanced data analysis methods, including the Boruta algorithm and random forest, were employed to compare plasma profiles in the three breeds. The level of 11, 14 and five metabolites differed between Italian Duroc and Italian Large White breeds, Italian Duroc and Italian Landrace breeds and Italian Large White and Italian Landrace breeds, respectively. Distinct breed-related metabolic profiles emerged, aligning with known characteristics of the breeds. Specifically, Italian Duroc pigs are marked by diminished biogenic amine levels, Italian Large White pigs by lower sphingomyelin levels, and Italian Landrace by elevated acylcarnitine and phosphatidylcholine levels. These results suggest potential differences in breed-related energy and lipid metabolism strategies. These findings could be used to develop new molecular phenotypes useful in pig breeding and selection and to explore breed-precision feeding strategies.

Indexed as

MetabolomeMetabolomicsAnimalsBreedingCarnitineItalyPhenotypePhosphatidylcholinesSphingomyelinsSwineCarnitinePhosphatidylcholinesSphingomyelinsBloodLipid metabolismMachine learningMetaboliteMetabolomicsSus scrofa

Identifiers

PMID41214166
PMCPMC12603176

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.