Evidence map›Paper›PMID 41214256›Full record

Trial reportAIDS and behavior2026

Randomized Controlled Trial of Game Changers, a Social Network Intervention for HIV Prevention in Uganda.

Laura M Bogart, Joseph K B Matovu, Harold D Green, Susan Ninsiima, David J Klein, Violet Gwokyalya, Richard Serunkuuma, Bonnie Ghosh-Dastidar, Kuraish Mubiru, Milly Nabukeera and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05098015 (Controlled Trial of Game Changers), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05098015 nacompletednot on this map

Controlled Trial of Game Changers: A Group Intervention to Train HIV Clients to be Change Agents for HIV Prevention in Uganda

TypeinterventionalSponsorRANDRan2022 to 2024Enrolled809ConditionsHIV PreventionArmsGame Changers
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Laura M Bogart *RAND, 1776 Main Street, P.O. Box 2138, Santa Monica, CA, 90407-2138, USA. lbogart@rand.org.ORCID http://orcid.org/0000-0003-3182-5542
Joseph K B Matovu *Makerere University School of Public Health, Kampala, Uganda.
Harold D GreenIndiana University School of Public Health-Bloomington, Bloomington, IN, USA.
Susan NinsiimaInfectious Diseases Institute, Kampala, Uganda.
David J KleinRAND, 1776 Main Street, P.O. Box 2138, Santa Monica, CA, 90407-2138, USA.
Violet GwokyalyaMakerere University School of Public Health, Kampala, Uganda.
Richard SerunkuumaNational Forum of People Living With HIV/AIDS Networks in Uganda (NAFOPHANU), Kampala, Uganda.
Bonnie Ghosh-DastidarRAND, 1776 Main Street, P.O. Box 2138, Santa Monica, CA, 90407-2138, USA.
Kuraish MubiruNational Forum of People Living With HIV/AIDS Networks in Uganda (NAFOPHANU), Kampala, Uganda.
Milly NabukeeraNational Forum of People Living With HIV/AIDS Networks in Uganda (NAFOPHANU), Kampala, Uganda.
Nipher MalikaRAND, 1776 Main Street, P.O. Box 2138, Santa Monica, CA, 90407-2138, USA.
Stephen Okoboi *Infectious Diseases Institute, Kampala, Uganda.
Glenn J Wagner *RAND, 1776 Main Street, P.O. Box 2138, Santa Monica, CA, 90407-2138, USA.

Funding

Policy Impact CoreP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1997 to 2025
$16.4M
A Hybrid Implementation-Effectiveness Trial of Game Changers for Cervical Cancer Prevention in UgandaR01CA282284 · RAND CORPORATION · 2025 to 2025
$792k
Controlled Trial of Game Changers: A Group Intervention to Train HIV Clients to be Change Agents for HIV Prevention in UgandaR01MH126691 · RAND CORPORATION · 2025 to 2025
$720k
NCI NIH HHS R01 CA282284NIMH NIH HHS P30 MH058107NIMH NIH HHS R01 MH126691
6 · The paper itself

Abstract

In Uganda, where HIV prevalence remains above 5% among those aged 15 and older, we conducted a randomized controlled trial of Game Changers, an 8-session peer-facilitated group intervention that empowers people living with HIV (PLHIV) to engage in HIV prevention advocacy with their social network members ("alters"). A total of 210 index PLHIV participants (105 intervention, 105 control) and 599 alters were enrolled; assessments were conducted at baseline and 6-, 12-, and 18-months post-baseline. Intention-to-treat repeated measures regressions indicated significant intervention effects on reduced internalized stigma and increased HIV prevention advocacy, prevention advocacy self-efficacy, and disclosure among index participants. In within-intervention group analyses, alters exposed to prevention advocacy showed higher likelihoods of HIV testing and condom use. Game Changers had direct psychosocial benefits for index participants, and indirect benefits for improved HIV prevention behaviors among alters. Implementation research is needed to determine conditions under which Game Changers is most effective.NCT05098015, Registered 2021-10-18.

Indexed as

HIV InfectionsSocial NetworkingSocial SupportAdolescentAdultCondomsFemaleHumansMaleMiddle AgedPeer GroupSelf EfficacySocial StigmaUgandaYoung AdultHIVInterventionPrevention advocacyRandomized controlled trialSocial networkStigma

Identifiers

PMID41214256
PMCPMC12614433

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.