ReviewNature reviews. Gastroenterology & hepatology2026
IL-1 family of cytokines in gastrointestinal and liver disorders.
Review in Nature reviews. Gastroenterology & hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Inflammatory gut-liver crosstalk: mechanisms and therapeutic targets.Experimental & molecular medicine · 2026Review
- Association of adverse childhood experiences and gastrointestinal and liver diseases among middle-aged and elderly adults in China.Epidemiology and psychiatric sciences · 2026Article
- MASLD, diabetes and PMOS across the female life stages.Diabetologia · 2026Review
- Optogenetic activation of liver-innervating vagal sensory neurons increases anxiety-like behavior in mice.Translational psychiatry · 2026Article
- A liver-heart endocrine axis revealed by systems genetics and mediated by hepatocyte growth factor activator.medRxiv : the preprint server for health sciences · 2026Article
- Lactobacillus salivarius li01 alleviates premature ovarian insufficiency via gut microbiota-mediated modulation of tryptophan metabolism.NPJ science of food · 2026Article
- Palmitic acid activates c-Myc via dual palmitoylation-dependent pathways to promote colon cancer.Cell discovery · 2026Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation has a fundamental role in many disorders of the gastrointestinal tract and the liver. Why these organs are particularly prone to acute, but especially chronic, immune-mediated disorders remains unclear; however, the complex exposure to environmental triggers, including the gut microbiota, might be particularly relevant. Cytokines are considered key regulators of inflammatory processes, with IL-1β being one of the first cytokines discovered, more than four decades ago. A whole family of IL-1-related cytokines has been discovered, and their crucial role in many gastrointestinal and liver diseases has been studied in detail. Today, the IL-1 family comprises 22 members, including 11 cytokines and 11 receptors. IL-1 signalling cascades share similarities with Toll-like receptors, initiating acute-phase reactions to environmental and endogenous threats, and are particularly involved in orchestrating innate immune responses, which are the basis of many gastrointestinal and liver disorders. In this article, we discuss the role of the main IL-1 family members in gastrointestinal and liver diseases, focusing on preclinical and clinical research, and we contemplate opportunities for clinical applications.
Indexed as
Identifiers
41214288What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.