Evidence map›Paper›PMID 41214609›Full record

ReviewBMC pulmonary medicine2025

Extracellular vesicles in pulmonary diseases: roles and therapeutic potential.

Madison Coward-Smith, Razia Zakarya, Brian Gg Oliver, Richard Y Kim, Chantal Donovan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Madison Coward-SmithSchool of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia. Madison.CowardSmith@uts.edu.au.
Razia ZakaryaSchool of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
Brian Gg OliverSchool of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
Richard Y Kim *School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
Chantal Donovan *School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are small lipid bilayer packages responsible for cellular communication. Increasing clinical and experimental evidence strongly links EVs to homeostasis and the pathogenesis of disease. In this review, we provide a brief overview of EVs and their biological significance in pulmonary disease. We outline the current challenges in diagnosis and treatment of lung diseases and discuss the rationale for exploring EVs as a novel therapeutic avenue. Beyond their biomarker potential, we outline the role and potential for therapeutic targeting of EVs in the pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and infectious diseases. We also explore the current literature on the use of stem cell derived EVs to drive lung repair and regeneration in inflammatory diseases. Lastly, we highlight challenges and limitations of the study of EVs in pulmonary disease and provide future perspectives with exciting opportunities for translation into therapy.

Indexed as

Extracellular VesiclesLung DiseasesAsthmaBiomarkersHumansLung NeoplasmsPulmonary Disease, Chronic ObstructiveBiomarkersExtracellular vesiclesImmune modulationInfectionPulmonary diseaseTherapeutic opportunity

Identifiers

PMID41214609
PMCPMC12604239

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.