ArticleVeterinary research2025
Transcriptomic landscape of pseudorabies virus-induced encephalitis reveals key lncRNAs involved in host-neurotropic virus interactions.
Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Comparative Transcriptomic Analysis Reveals Divergent Host Cell Responses to Classical and Variant Pseudorabies Virus Strains.Veterinary sciences · 2026Article
- Animal virus-host interactions mediated by non-coding RNAs.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Pseudorabies virus (PRV) infection causes fatal encephalitis across various species, a condition known as pseudorabies encephalitis (PRE). However, the molecular mechanisms underlying PRE remain poorly understood. Long noncoding RNAs (lncRNAs) have emerged as important regulators of gene expression in neurological diseases and viral infections. This study explores genome-wide transcriptional alterations in a mouse model of PRV-induced encephalitis. The intranasal inoculation of mice with PRV induced severe encephalitis, characterized by high viral loads, significant inflammatory responses, and the onset of neurological symptoms. RNA-seq analysis revealed 683 differentially expressed (DE) mRNAs and 179 DElncRNAs in PRV-infected brains compared with controls. Functional and pathway analyses revealed that PRE involves neurodegeneration and diverse immune responses, reflecting the complex interplay between viral evasion strategies and host defenses. Co-expression network analysis, supported by experimental validation, identified several lncRNAs as central hubs interacting with multiple immune-related genes and exhibiting cell type-specific expression pattern. Notably, ZFAS1 was prominently dysregulated in PRV-infected microglia and showed extensive co-expression connectivity. Knockdown of ZFAS1 modulated microglia-driven inflammation without altering viral replication, underscoring its potential as a therapeutic target for mitigating neuroinflammation in virus-associated neurological diseases. The identification of key lncRNAs and their potential regulatory roles deepens our understanding of disease mechanisms, while offering new avenues for therapeutic intervention in neurotropic viral infections.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.