Evidence map›Paper›PMID 41214866›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

NOX2-Driven Oxidative Stress Promotes EndMT and Uncouples Angiogenesis-Osteogenesis at the Bone-Implant Interface in Diabetes.

Zimei Wu, Qiaodan Hou, Yang Liu, Tingting Chen, Kunkun Yang, Luyao Li, Lin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zimei WuDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China.
Qiaodan HouDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China.
Yang LiuDepartment of Biomedical Engineering, Southern University of Science and Technology, Nanshan District, Shenzhen, 518055, P. R. China.
Tingting ChenDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China.
Kunkun YangDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China.
Luyao LiDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China.
Lin WangDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China.ORCID https://orcid.org/0000-0002-5995-8446

Funding

National Natural Science Foundation of China 82372378Shenzhen Science and Technology Program JCYJ20240813095113019Shenzhen Science and Technology Program JCYJ20240813150417023Shenzhen Science and Technology Program JCYJ20250604143507009The Medical Research Innovation Project G030410001
6 · The paper itself

Abstract

Diabetes undermines implant integration, yet how the bone-implant interface (BII) can be rationally re-engineered remains unclear. Here endothelial NOX2-driven oxidative stress is identified as a mechanistic switch that triggers endothelial-to-mesenchymal transition (EndMT), depletes type-H (CD31

Indexed as

Bone-Implant InterfaceDiabetes Mellitus, ExperimentalEpithelial-Mesenchymal TransitionNADPH Oxidase 2Neovascularization, PhysiologicOsteogenesisOxidative StressAngiogenesisAnimalsEndothelial-Mesenchymal TransitionHumansMaleMiceCybb protein, mouseNADPH Oxidase 2angiogenesis–osteogenesis couplingdiabetesEndMTNOX2osseointegrationtitanium–bone interface

Identifiers

PMID41214866
PMCPMC12822455

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.