Evidence map›Paper›PMID 41215544›Full record

ArticlePharmaceutical biology2025

Exploring chemical composition, anti-acetylcholinesterase, and anticancer activities of

Chahrazad Bakka, Huseyin Akşit, Wafa Zahnit, Bihter Şahin, Ali Aydin, Ozge Tokul-Olmez, Mehmet Ozturk, Ouanissa Smara, Hocine Dendougui, Mohamed Hadjadj and 2 more

Abstract read
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In one paragraph

Article in Pharmaceutical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chahrazad BakkaDepartment of Chemistry, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Laboratory of Valorization and Promotion of Saharan Resources (VPRS), Ouargla, Algeria.
Huseyin AkşitFaculty of Pharmacy, Department of Analytical Chemistry, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Wafa ZahnitDepartment of Chemistry, Faculty of Sciences, University of Ferhat ABBAS Setif 1, Algeria.
Bihter ŞahinDepartment of Chemistry and Chemical Processing, Susurluk Agriculture and Forest Vocational School, Bandırma Onyedi Eylül University, Susurluk-Balıkesir, Turkey.
Ali AydinDepartment of Basic Medical Science, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Ozge Tokul-OlmezDepartment of Chemistry, Faculty of Science, Mugla Sıtkı Koçman University, Mugla, Turkey.
Mehmet OzturkDepartment of Chemistry, Faculty of Science, Mugla Sıtkı Koçman University, Mugla, Turkey.
Ouanissa SmaraDepartment of Chemistry, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Laboratory of Valorization and Promotion of Saharan Resources (VPRS), Ouargla, Algeria.
Hocine DendouguiDepartment of Chemistry, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Laboratory of Valorization and Promotion of Saharan Resources (VPRS), Ouargla, Algeria.
Mohamed HadjadjDepartment of Chemistry, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Laboratory of Valorization and Promotion of Saharan Resources (VPRS), Ouargla, Algeria.
Ayomide Victor AtokiDepartment of Biochemistry, Kampala International University, Ishaka, Uganda.ORCID 0000-0003-1914-973X
Mohammed MessaoudiLaboratoire de Recherche sur les Produits Bioactifs et Valorisation de la Biomasse, Département de Chimie, ENS Kouba, Alger, Algeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe Atlas Pistachio (

objectiveWe set out to test various extracts from MATERIALS AND

methodsThe anti-acetylcholinesterase activity was performed against the acetylcholinesterase (AChE) enzyme. Anticancer assays were investigated by evaluating the antiproliferative and cytotoxicity potentials against five cancerous cell lines using the [3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] (MMT:Medical training therapy) assay. The phenolic profile was established against phenolic standards using high-performance liquid chromatography with diode-array detection (HPLC-DAD).

resultsIn anticholinesterase activity, the extracts of DISCUSSION AND

conclusionThis study demonstrated moderate anticholinesterase and suitable antiproliferative activities of

Indexed as

Antineoplastic Agents, PhytogenicCholinesterase InhibitorsPistaciaPlant ExtractsAcetylcholinesteraseCell Line, TumorCell ProliferationCell SurvivalChromatography, High Pressure LiquidDose-Response Relationship, DrugFruitHumansPhenolsPlant LeavesAcetylcholinesteraseAntineoplastic Agents, PhytogenicCholinesterase InhibitorsPhenolsPlant ExtractsAnti-acetylcholinesteraseanticancerHPLC-DADphenolic compoundsPistacia atlantica Desf

Identifiers

PMID41215544
PMCPMC12608110

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.