ArticleJournal of medicinal chemistry2026
Antibacterial Benzimidazole-2-Methanamines as Allosteric Modulators of
Homero Dominguez-Cisneros, Mohini Mohan Konai, Choon Kim, Neha Rana, Rhona Feltzer, Jeshina Janardhanan, Amr M El-Araby, Van T Nguyen, Jed F Fisher, Mayland Chang and 1 more
Abstract read
In one paragraphArticle in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Homero Dominguez-CisnerosDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Mohini Mohan KonaiDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0009-0003-5369-1597 Choon KimDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0003-0306-8935 Neha RanaDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Rhona FeltzerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Jeshina JanardhananDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Amr M El-ArabyDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-3143-8801 Van T NguyenDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Jed F FisherDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Mayland ChangDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-4333-3775 Shahriar MobasheryDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID 0000-0002-7695-7883 Funding
Targeting Gram-Negative Bacteria for Antibacterial StrategiesR35GM158092 · NIGMS · UNIVERSITY OF NOTRE DAME · PI Shahriar Mobashery · 2025 to 2026
$829kNIGMS NIH HHS R35 GM158092
6 · The paper itselfAbstract
The allosteric site of penicillin-binding protein 2x (PBP2x), an essential enzyme of cell-wall biosynthesis of
Indexed as
Anti-Bacterial AgentsBenzimidazolesPenicillin-Binding ProteinsStreptococcus pneumoniaeAllosteric RegulationAllosteric SiteMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial AgentsBenzimidazolesPBP 2x protein, StreptococcusPenicillin-Binding Proteins
Identifiers
PMID41215557
PMCPMC13288780
What Socratic holds
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