Evidence map›Paper›PMID 41215608›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Golgi-Targeted Viscosity Fluorescent Probe for Monitoring Acute Lung Injury.

Yaqian Li, Zi Yang, Jieni Lei, Qiuzi Dai, Guangyi Li, Hai Xu, Jiaoyang Lu, Juyoung Yoon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yaqian LiHunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, The First Clinical College of Changsha Medical University, Changsha, 410219, P. R. China.
Zi YangHunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, The First Clinical College of Changsha Medical University, Changsha, 410219, P. R. China.
Jieni LeiHunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, The First Clinical College of Changsha Medical University, Changsha, 410219, P. R. China.
Qiuzi DaiHunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, The First Clinical College of Changsha Medical University, Changsha, 410219, P. R. China.
Guangyi LiHunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, The First Clinical College of Changsha Medical University, Changsha, 410219, P. R. China.
Hai XuDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Jiaoyang LuHunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, The First Clinical College of Changsha Medical University, Changsha, 410219, P. R. China.
Juyoung YoonDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.ORCID https://orcid.org/0000-0002-1728-3970

Funding

Korea government RS-2023-00217701Ministry of Science and ICT RS-2024-00407093National Natural Science Foundation of China 32201108National Research Foundation of KoreaScience and Technology Innovation Program of Hunan Province 2022RC1167Scientific Research Fund of Hunan Provincial Education Department 22C0672Scientific Research Fund of Hunan Provincial Education Department 23B0883Scientific Research Fund of Hunan Provincial Education Department 23C0447Scientific Research Fund of Hunan Provincial Education Department 24B0891Scientific Research Fund of Hunan Provincial Education Department 24B0893the Natural Science Foundation of Hunan Province 2022JJ40529the Natural Science Foundation of Hunan Province 2023JJ40084the Natural Science Foundation of Hunan Province 2024JJ5053the Natural Science Foundation of Hunan Province 2025JJ60753
6 · The paper itself

Abstract

Acute lung injury (ALI) is a severe respiratory disorder driven by uncontrolled inflammation, where early diagnosis and intervention are critical. Recent evidence implicates Golgi apparatus dysfunction in ALI progression, but its biophysical changes remain unexplored. Here, we report GV, a novel Golgi-targeted fluorescent probe with high photostability, low cytotoxicity, and excellent specificity, enabling sensitive imaging of viscosity changes under stress. Using both cellular and mouse models of ALI, we demonstrated a significant increase in Golgi viscosity during disease progression. These findings suggest that Golgi viscosity may serve as a potential biomarker for ALI and establish GV as a powerful tool for investigating organelle-level biophysical alterations in inflammatory diseases.

Indexed as

Acute Lung InjuryFluorescent DyesGolgi ApparatusAnimalsDisease Models, AnimalHumansMiceViscosityFluorescent DyesAcute lung injuryFluorescent probeGolgi targetedViscosity

Identifiers

PMID41215608
PMCPMC12712764

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.