Evidence map›Paper›PMID 41215769›Full record

ArticleMaterials today. Bio2025

EUK nanozyme-loaded PL&GA coacervate droplets attenuate ulcerative colitis through restoring gut homeostasis and restricting intestinal cell ferroptosis.

Mingxia Zhou, Linping Lu, Xinyu Xu, Yefan Zhou, Huan Fang, Xue Wang, Dongxu Li, Xiaoyan Li, Jiaqi Hua, Jiahe Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Antioxidants (Basel, Switzerland) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mingxia ZhouDepartment of Gastroenterology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Linping LuDepartment of Gastroenterology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Xinyu XuDepartment of Medical Laboratory, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Yefan ZhouDepartment of Medical Laboratory, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Huan FangDepartment of Gastroenterology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Xue WangDepartment of Medical Laboratory, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Dongxu LiDepartment of Gastroenterology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Xiaoyan LiDepartment of General Surgery, Huashan Hospital of Fudan University, Shanghai, Shanghai, 200040, China.
Jiaqi HuaDepartment of Medical Laboratory, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Jiahe LiuDepartment of Breast Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Yingxia LiDepartment of Gastroenterology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Libin JiangDepartment of Gastroenterology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Qiuju MiaoMedical 3D Printing Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Hongtao WenDepartment of Gastroenterology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Jing HeDepartment of Breast Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Shenyu YangMedical 3D Printing Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), manifests as chronic diarrhea, abdominal pain, and bloody mucoid stools. Current treatment approaches for UC are typically limited by inadequate targeted delivery, premature gastrointestinal degradation, and systemic off-target effects. To address these challenges, we engineered PL&GA@EUK, EUK-134 nanozymes encapsulated in polylysine (PL) and glycyrrhizic acid (GA) coacervate droplets. PL&GA@EUK exhibited potent superoxide dismutase- and catalase-mimetic activities, scavenging hydroxyl radicals and demonstrating anti-inflammatory efficacy in both

Indexed as

Coacervate dropletFerroptosisIntestinal homeostasisMicrobiotaROSUlcerative colitis

Identifiers

PMID41215769
PMCPMC12596215

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.