Evidence map›Paper›PMID 41215804›Full record

ArticlePeerJ2025

Prognostic implications of microRNA-107 in esophageal cancer: a retrospective cohort study.

Jie Sun, Jin Zhang, Jingwen Ye, Yuqi Chen, Caifeng Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jie Sun *Department of Gastroenterology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Jin Zhang *Department of Pathology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, Jiangsu, China.
Jingwen YeDepartment of Gastroenterology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yuqi ChenDepartment of Gastroenterology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Caifeng JiangDepartment of Gastroenterology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Esophageal squamous cell carcinoma (ESCC) imposes a heavy disease burden in China, accounting for over 50% of global cases and approximately 301,000 annual deaths. Current prognostic markers inadequately predict recurrence in early-stage patients. This study investigates microRNA-107 (miR-107) as a novel prognostic biomarker for ESCC. Methods: Tumor tissues ( Results: miR-107 expression was significantly lower in esophageal cancer tissues (0.801 ± 0.737) compared to adjacent non-cancerous tissues (1.390 ± 1.346), Conclusions: miR-107 downregulation is a robust predictor of aggressive ESCC phenotypes and poor survival. It holds promise as a clinical biomarker for risk stratification and personalized therapy. Future studies should validate these findings in multicenter cohorts and elucidate miR-107's functional mechanisms.

Indexed as

Biomarkers, TumorEsophageal NeoplasmsMicroRNAsAgedCell Line, TumorChinaEsophageal Squamous Cell CarcinomaFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisRetrospective StudiesBiomarkers, TumorMicroRNAsMIRN107 microRNA, humanEsophageal squamous cell carcinomaMiR-107Molecular stagingPrognostic biomarkerSurvival analysis

Identifiers

PMID41215804
PMCPMC12596877

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.