Evidence map›Paper›PMID 41216005›Full record

ReviewInternational journal of cardiology. Heart & vasculature2025

Multidimensional optimization of stent design for endothelial shear stress regulation: Geometric structuring, surface functionalization strategies to mitigate thrombosis and restenosis.

Mengyuan Che, Liuliu Feng, Xinbing Liu, Liangfeng Zhao, Suying Zhou, Xinyu Zhong, Lingsen You, Yu Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of cardiology. Heart & vasculature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengyuan CheDepartment of Cardiology, Shidong Hospital affiliated to University of Shanghai for Science and Technology, 999 Shiguang Road, Shanghai 200438, China.
Liuliu FengDepartment of Cardiology, Shidong Hospital affiliated to University of Shanghai for Science and Technology, 999 Shiguang Road, Shanghai 200438, China.
Xinbing LiuDepartment of Cardiology, Shidong Hospital affiliated to University of Shanghai for Science and Technology, 999 Shiguang Road, Shanghai 200438, China.
Liangfeng ZhaoDepartment of Cardiology, Shidong Hospital affiliated to University of Shanghai for Science and Technology, 999 Shiguang Road, Shanghai 200438, China.
Suying ZhouDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.
Xinyu ZhongDepartment of Cardiology, Shidong Hospital affiliated to University of Shanghai for Science and Technology, 999 Shiguang Road, Shanghai 200438, China.
Lingsen YouDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.
Yu WangDepartment of Cardiology, Shidong Hospital affiliated to University of Shanghai for Science and Technology, 999 Shiguang Road, Shanghai 200438, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The occurrence of in-stent restenosis (ISR) is closely associated with abnormal distribution of endothelial shear stress (ESS), and optimizing stent design is crucial for improving patient prognosis. This review aims to comprehensively explore how stent design parameters-including geometric structure and surface functionalization-influence neointimal hyperplasia and thrombosis by modulating ESS, while also summarizing the latest technological strategies. A detailed discussion is provided on the design evolution from traditional coronary stents to for non-coronary arteries (cerebral aneurysm) micro-woven stents, analyzing the mechanisms by which factors such as streamlined profiles, reduced strut thickness, and optimized spacing improve hemodynamics. Furthermore, the article critically evaluates the advantages and current limitations of cutting-edge technologies such as computational fluid dynamics (CFD)-based optimization and endothelialization-promoting functional coatings. We conclude that multidimensional stent design optimization represents a future trend in regulating ESS and suppressing restenosis. Future research should focus on integrating personalized design with highly biocompatible materials to advance the clinical translation of next-generation vascular stents.

Indexed as

AtherosclerosisEndothelial shear stressIn-stent restenosisStent designStent implantationThrombosis

Identifiers

PMID41216005
PMCPMC12596675

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.