ArticleBurns & trauma2025
Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells' mitochondrial function via sonic hedgehog signaling.
Article in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Current trends in electrospun nanofibers combined with mesenchymal stem cells for diabetic foot ulcer repair and regenerative therapy.iScience · 2026Review
- Tubular Omega-3 Fatty Acid Receptor FFAR4 Deficiency Aggravated Renal Aging and Chronic Kidney Disease.Aging cell · 2026Article
- Forecasting the global burden of peripheral artery disease: implications for wound healing and healthcare systems.Burns & trauma · 2026Article
- Diabetes, Obesity, and the Metabolic Drivers of Peripheral Artery Disease: Lessons from Recent Forecasts.Vascular health and risk management · 2026Review
- Interpretable machine learning model for predicting recurrence in patients with diabetic foot ulcers.BMJ open diabetes research & care · 2025Article
- Synergistic effects of platelet-rich fibrin and CTLA4Ig gene-transfected porcine skin on accelerating wound healing in a rat model of deep second-degree burns: a mechanistic study.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetic foot ulcer (DFU) is a common and debilitating complication of diabetes, often leading to delayed wound healing. The peroxisome proliferator-activated receptors (PPARs) play a crucial role in regulating cellular metabolism and promoting angiogenesis. This study aims to elucidate the mechanisms through which the activation of PPARs enhances wound healing, particularly under diabetic conditions, as these mechanisms remain inadequately understood. Methods: Differentially expressed genes in DFU wounds and normal skin tissues were identified using the GEO database. PPAR expression in DFU neovascularization was validated by quantitative reverse transcription polymerase chain reaction, immunofluorescence, and western blotting. Results: PPAR expression was significantly downregulated in DFU tissues ( Conclusions: PPAR signaling plays a critical role in DFU healing, with its inhibition linked to vascular dysfunction. Activation of the PPARs/SHH-mitochondrial axis significantly enhances endothelial cell metabolism and angiogenesis. This study provides insights into the molecular mechanisms of diabetic wound healing and supports the clinical potential of PPAR agonists for DFU treatment.
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Registered trials
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