Regulator of chromosome condensation 1 and broad-complex, tramtrack and bric a brac domain-containing protein is involved in ovarian cancer growth and drug resistance.

Gaowa Zhao, Xiaochao Xiao, Limeng Song, Bangruo Qi

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In one paragraph

Article in CytoJournal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Gaowa Zhao *Department of Gynecology, The Inner Mongolia People's Hospital, Hohhot, China.

Xiaochao Xiao *Department of Gynecology, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Hainan, China.

Limeng SongDepartment of Gynecology, The Inner Mongolia People's Hospital, Hohhot, China.

Bangruo QiDepartment of Central Laboratory, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Hainan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Ovarian cancer (OC) is the most common and deadliest cancer in women worldwide. The high incidence and mortality rates highlight the serious threat that OC poses to women's health. Regulator of chromosome condensation (RCC1) and broad-complex, tramtrack and bric a brac ( BTB) domain-containing protein 1 (RCBTB1), which includes the RCC1 and BTB domains, is a cell proliferation-related protein. This study aims to reveal the role of RCBTB1 in OC and its possible pathway. Material and Methods: The expression of RCBTB1 in OC cells was measured by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC). Transwell assay, wound-healing assay, clone formation assay, IHC, immunofluorescence, and methylthiazolyldiphenyl-tetrazolium bromide assay were used to evaluate the effect of silencing RCBTB1 Results: The A2780 cells had increased RCBTB1 expression ( Conclusion: RCBTB1 may regulate the NF1/Ras signaling axis, which is critical for OC and MEK inhibitor resistance. This research offers a unique therapeutic approach for ovaries with KRAS mutations and uncovers a previously unknown connection between RCBTB1 and NF1/Ras signaling.

Indexed as

Kirsten rat sarcoma viral oncogene mutationsNeurofibromin 1/rat sarcoma signaling axisOvarian cancerRegulator of chromosome condensation 1 and BTB domain-containing protein 1

Identifiers

PMID41216235

DOI10.25259/Cytojournal_268_2024

PMCPMC12596774

What Socratic holds

Textmetadata

LicenceCC BY-NC-SA

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.