Evidence map›Paper›PMID 41216919›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

The Egyptian Dementia Network (EDN): Baseline characteristics from the first dementia registry in an African Arab country.

Shimaa A Heikal, Gharib Fawi, Eman M Khedr, Mai Othman, Sara A Moustafa, Nesma G Elsheikh, Heba M Tawfik, Sara Elfarrash, Samer Salama, Eman M Ali and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Alzheimer's & dementia (New York, N. Y.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shimaa A HeikalInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.ORCID 0000-0002-0798-1863
Gharib FawiNeurology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Eman M KhedrNeuropsychiatry Department, Assiut University, Assiut, Egypt.
Mai OthmanInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Sara A MoustafaInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Nesma G ElsheikhGeriatric Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Heba M TawfikGeriatric Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Sara ElfarrashMedical Physiology Department, Faculty of Medicine, Mansoura University, and Medical Experimental Research Centre (MERC), Mansoura, Egypt.
Samer SalamaNeurology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Eman M AliCommunity Nursing Department, Faculty of Nursing, Beni-Suef University, Beni-Suef, Egypt.
Hany I HassaninGeriatric Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohamed SalamaInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.

Funding

100 PhDs for Africa programmeAmerican University in Cairo, Research SupportUM6P- EPFL Excellence in Africa Initiative
6 · The paper itself

Abstract

introductionDementia is a growing public health challenge in low- and middle-income countries (LMICs) like Egypt, where data are scarce. The Egyptian Dementia Network (EDN) registry addresses this gap by capturing epidemiological, clinical, and environmental data across Egypt.

methodsIn this multicenter study, 662 participants from six governorates were enrolled using standardized tools.

resultsThe cohort had advanced age (mean 68.3 years), low education (65.9% illiterate), and high comorbidities including hypertension (55%) and diabetes (23%). Alzheimer's disease (62%) and vascular dementia (23%) predominated. Only 24.4% received pharmacological treatment and 2.1% psychosocial support, highlighting care gaps. Household insecticide exposure (20.4%) was notable. DISCUSSION: EDN demonstrates the feasibility of implementing a national dementia registry in LMICs, generating baseline insights into demographic, clinical, and environmental risks. In addition, registry-linked biosamples have enabled pilot multi‑omics and exposome analyses, underscoring its potential as a scalable scientific platform for future dementia research. HIGHLIGHTS: Established Egypt's first national, multicenter dementia registry. Aimed to characterize dementia profiles and care gaps across diverse regions. Identified late-stage diagnosis and limited access to dementia interventions. Uncovered unique environmental risk factors relevant to the Egyptian context. Provides a foundation for policy, research, and improved dementia care in Egypt.

Indexed as

DementiaRegistriesAgedAged, 80 and overComorbidityEgyptFemaleHumansMaleMiddle AgedAlzheimer's diseasedementiadiagnosisEgyptenvironmental exposureLMIClow‐ and middle‐income countrymultimorbidityregistryrisk factors

Identifiers

PMID41216919
PMCPMC12603777

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.