ArticleClinical and experimental medicine2025
Construction of a prognostic model for nasopharyngeal carcinoma based on serum exosomal circular RNAs and analysis of immune microenvironment.
Article in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- CircSPARC mediates an immunosuppressive tumor microenvironment by regulating the miR-199a-5p/LASP1 axis in non-small cell lung cancer.BMC pulmonary medicine · 2026Article
- Orbital Metastases of Breast Cancer: Case Report and Review of the Literature.Oncology research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence indicates that circular RNAs (circRNAs) play a pivotal role in tumor initiation and progression. However, their expression profiles and functional roles in serum exosomes from nasopharyngeal carcinoma (NPC) remain undefined. This study aims to explore the expression patterns, biological functions, and potential prognostic significance of circRNAs in serum exosomes of NPC. CircRNA expression profiles in serum exosomes were analyzed using a circRNA microarray, along with mRNA and miRNA data from RNA sequencing and the Gene Expression Omnibus (GEO). Initially, the competitive endogenous RNA (ceRNA) regulatory network was established by integrating multiple online databases and bioinformatics tools. Subsequently, LASSO and COX regression analyses were used to construct and validate the prognostic model. Additionally, the immunological characteristics analysis was conducted using CIBERSORT. qRT-PCR was performed to further validate the expression levels of circRNAs. Finally, a total of 314 differentially expressed circRNAs were identified in NPC serum exosomes, and a ceRNA regulatory network was constructed for three of them. The prognostic risk model effectively predicts outcomes for NPC patients. Immune cell infiltration analysis revealed a significant increase in M1-type macrophages in the high-risk group, whereas the low-risk group exhibited elevated levels of resting mast cells and activated CD4 memory T cells. Additionally, immune checkpoint gene analysis revealed significantly higher expression of CD276 and ICOSLG in the high-risk group compared to the low-risk group. Our findings suggest that serum exosomal circRNAs may be promising prognostic biomarkers in NPC, warranting further functional and clinical validation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.