Evidence map›Paper›PMID 41217840›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Impaired cooperation and prosocial learning during trust game in behavioral variant frontotemporal dementia.

Jayden J Lee, Jiangmei Xiong, Tony X Phan, Jerica E Reeder, Lindsey C Keener, Matthias G Tholen, Simon Vandekar, David H Zald, R Ryan Darby

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jayden J LeeDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-3611-4187
Jiangmei XiongDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Tony X PhanDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jerica E ReederDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Lindsey C KeenerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Matthias G TholenUniversity Hospital of Psychiatry, Psychotherapy and Psychosomatics, Paracelsus Medical University, Salzburg, Austria.
Simon VandekarDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-7457-9073
David H ZaldCenter for Advanced Human Brain Imaging Research, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0002-1229-2923
R Ryan DarbyDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Cognitive and Neural Mechanisms of Antisocial Behavior in Frontotemporal DementiaK23AG070320 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DARBY, RICHARD RYAN · 2021 to 2025
$857k
NIA NIH HHS K23 AG070320
6 · The paper itself

Abstract

BackgroundInterpersonal trust and cooperation are important aspects of prosocial behavior. Dementia can alter social cognition, but it remains unclear how these changes alter propensity to trust and willingness to cooperate with others, and whether there are differences between types of dementia.ObjectiveTo determine if patients with behavioral variant frontotemporal dementia (bvFTD) differ from patients with Alzheimer's disease (AD) and cognitively normal controls in trusting behaviors and learning to cooperate.Methods38 bvFTD patients, 20 AD patients and 26 cognitively normal participants invested money in two separate partners to receive a proportion of the profit in return. One partner returned a fair proportion of the investment (

Indexed as

Cooperative BehaviorFrontotemporal DementiaLearningSocial BehaviorTrustAgedAlzheimer DiseaseFemaleGames, ExperimentalHumansMaleMiddle AgedNeuropsychological TestsAlzheimer's diseasebehaviorcooperationfrontotemporal dementiaperspective-takingprosocialreciprocityreinforcement learningsocialsocial cognitiontrust

Identifiers

PMID41217840
PMCPMC12664923

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.