Evidence map›Paper›PMID 41217992›Full record

ArticleCancer medicine2025

Cytokine-Cytokine Receptor Interaction and Endocytosis are Common Pathways for Symptom Burden and Sickness Behavior Symptoms in Oncology Patients Undergoing Chemotherapy.

Carolyn S Harris, Kord M Kober, Joosun Shin, Lisa Morse, Kate R Oppegaard, Steven Paul, Marilyn J Hammer, Jon D Levine, Yvette P Conley, Christine A Miaskowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carolyn S HarrisSchool of Nursing, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-7080-4990
Kord M KoberSchool of Nursing, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-9732-3321
Joosun ShinSchool of Nusing, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-6883-4448
Lisa MorseSchool of Nursing, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-9490-8906
Kate R OppegaardVA Portland Health Care System, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-6358-6315
Steven PaulSchool of Nursing, University of California, San Francisco, California, USA.
Marilyn J HammerDana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9561-6144
Jon D LevineSchool of Medicine, University of California, San Francisco, California, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1784-6067
Christine A MiaskowskiSchool of Nursing, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-5170-2027

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics ApproachR37CA233774 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOBER, KORD MICHAEL · 2019 to 2025
$4.8M
Characterization of the Symptom Experience of Patients with Cutaneous Melanoma Receiving Immune Checkpoint Inhibitor TherapyR00CA286967 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carolyn Stigge Harris · 2025 to 2026
$402k
NCI NIH HHS CA134900NCI NIH HHS CA233774NCI NIH HHS R00 CA286967NCI NIH HHS R00CA286967NCI NIH HHS R01 CA134900NCI NIH HHS R37 CA233774
6 · The paper itself

Abstract

backgroundInflammation is associated with sickness behavior symptoms in patients receiving chemotherapy. However, its impact on symptom burden (i.e., higher number of concurrent symptoms) requires evaluation. Study purposes were to evaluate for differentially perturbed immune and/or inflammatory pathways between outpatients receiving chemotherapy with Low (i.e., 0-8) versus High (i.e., 16-38) symptom burden and identify common immune and/or inflammatory pathways among symptom burden and single sickness behavior symptoms.

methodsPrior to their second or third cycle of chemotherapy, oncology outpatients reported the occurrence of 38 symptoms using the Memorial Symptom Assessment Scale and provided a peripheral blood sample. Using previously identified symptom cutpoints, patients with Low versus High symptom burden were evaluated. Transcriptome-wide gene expression was quantified using RNA-sequencing (n = 213; RNA-seq sample) or microarray (n = 207; microarray sample) technologies. Pathway impact analyses (PIA) were performed and signaling pathways were defined with the Kyoto Encyclopedia of Genes and Genomes database. Fisher's combined probability test was used to identify perturbed pathways between the Low and High symptom burden groups across both samples (false discovery rate < 0.005).

resultsFor the RNA-seq sample, 159 patients had High and 54 patients had Low symptom burden. For the microarray sample, 135 patients had High and 72 patients had Low symptom burden. Of the 40 pathways that were perturbed between the Low and High symptom burden groups, 10 were involved in immune or inflammatory processes. Cytokine-cytokine receptor interaction and endocytosis pathways were the common pathways identified across this study and PIAs of single sickness behavior symptoms.

conclusionsThis study is the first to identify differentially perturbed immune and inflammatory signaling pathways that were associated with symptom burden in oncology patients receiving chemotherapy. Evaluation of interventions targeted at the cytokine-cytokine receptor interaction and endocytosis pathways may decrease the burden associated with single and multiple occurring symptoms.

Indexed as

CytokinesEndocytosisIllness BehaviorNeoplasmsReceptors, CytokineAdultAgedFemaleGene Expression ProfilingHumansInflammationMaleMiddle AgedSignal TransductionSymptom BurdenTranscriptomeCytokinesReceptors, Cytokinecancerchemotherapycutpointsgene expressionimmune systeminflammation

Identifiers

PMID41217992
PMCPMC12604674

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.