Trial reportBMJ open2025
Acute myocardial infarction diagnosis and treatment following implementation of a multicomponent intervention in Tanzania: the MIMIC pilot trial.
Trial report in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04563546 (Community and Physician Perceptions of Chest Pain and Prevalence of Acute Coronary Syndrome Among HIV-infected and -Uninfected Patients in Moshi, Tanzania), which is not on this map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Community and Physician Perceptions of Chest Pain and Prevalence of Acute Coronary Syndrome Among HIV-infected and -Uninfected Patients in Moshi, Tanzania
Who cites it
4 citing papers in PubMed.
- Sustainability and normalization of an intervention to improve evidence-based myocardial infarction care in Tanzania.Implementation science communications · 2026Article
- Long-Term Implementation and Effectiveness of a Quality Improvement Intervention for Myocardial Infarction in Tanzania.Annals of global health · 2026Article
- Article
- Effect of an emergency department-based educational intervention on medication adherence and disease understanding after acute myocardial infarction in Tanzania.Frontiers in public health · 2026Article
Corrections and comments
- Update of
Authors and funding
12 authors.
Funding
Abstract
backgroundIn Tanzania, acute myocardial infarction (AMI) is underdiagnosed, and uptake of evidence-based care is suboptimal. Using an implementation science approach, an intervention was developed to address local barriers to care: the Multicomponent Intervention for Improving Myocardial Infarction Care in Tanzania (MIMIC).
methodsThis sequential cohort design trial was conducted in a single northern Tanzanian emergency department (ED). During the preintervention phase (February-August 2023) and the postintervention phase (September 2023-August 2024), adults presenting with chest pain and/or dyspnoea were prospectively enrolled and their ED care was observed. AMI was defined by the Fourth Universal Definition criteria. Telephone follow-ups were conducted to ascertain 30-day mortality. Pearson's χ² was used to compare care before and after MIMIC implementation.
resultsA total of 275 participants were enrolled in the preintervention phase and 577 were enrolled in the postintervention phase. Following MIMIC implementation, significant increases were observed in ECG testing (89.4% of postintervention participants vs 55.3% preintervention, OR 6.82, 95% CI 4.79 to 9.79, p<0.001), troponin testing (78.0% of postintervention participants vs 41.4% preintervention, OR 4.99, 95% CI 3.67 to 6.83, p<0.001), and AMI case identification (24.4% of postintervention participants vs 14.9% preintervention, OR 1.84, 95% CI 1.26 to 2.73, p=0.002). Among participants with AMI, significant increases were observed in evidence-based treatment, including aspirin (71.6% among postintervention AMI participants vs 34.4% preintervention, OR 4.80, 95% CI 2.31 to 10.37, p<0.001), clopidogrel (65.2% among postintervention AMI participants vs 26.8% preintervention, OR 5.03, 95% CI 2.37 to 11.39, p<0.001) and heparin (43.2% among postintervention participants vs 4.9% preintervention, OR 13.76, 95% CI 3.99 to 93.79, p<0.001). Thirty-day survival among AMI participants did not change following MIMIC implementation (63.8% among postintervention AMI participants vs 61.0% preintervention, OR 1.31, 95% CI 0.54 to 2.31, p=0.739).
conclusionsThe MIMIC intervention was associated with large increases in uptake of AMI testing, case identification and evidence-based treatment in a single Tanzanian ED. Multisite studies are needed to evaluate the effect of MIMIC on AMI care in diverse settings across Tanzania. TRIAL REGISTRATION NUMBER: NCT04563546.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.