Evidence map›Paper›PMID 41219185›Full record

ArticleNature communications2025

Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status.

Yunyi Bian, Guangyao Shan, Guoshu Bi, Zhijie Xu, Jiaqi Liang, Yuanliang Yan, Wei Guo, Qihai Sui, Yanjun Yi, Haochun Shi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yunyi Bian *Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Guangyao Shan *Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-2993-5817
Guoshu Bi *Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-2187-5271
Zhijie XuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0003-2047-883X
Jiaqi LiangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-4738-4238
Yuanliang YanDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wei GuoDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0000-0001-8302-8292
Qihai SuiDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yanjun YiDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Haochun ShiDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Tao LuDepartment of Thoracic Surgery, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/ Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
Huan ZhangDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital& Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Qun WangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-4853-1727
Hong FanDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. fan.hong@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0002-2005-1150
Wei JiangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. jiang.wei1@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0003-0904-3990
Cheng ZhanDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. czhan10@fudan.edu.cn.ORCID http://orcid.org/0000-0001-8745-9276

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The resistance to KRAS-targeted therapies, particularly due to co-occurring gene mutations, remains a significant challenge. Through a metabolite library screening, we reveal that polyamines sensitize KRAS inhibitors only in KRAS

Indexed as

FerroptosisKelch-Like ECH-Associated Protein 1PolyaminesProto-Oncogene Proteins p21(ras)AnimalsCell Line, TumorDrug Resistance, NeoplasmHumansMiceMolecular Targeted TherapyMutationNF-E2-Related Factor 2Xenograft Model Antitumor AssaysKEAP1 protein, humanKelch-Like ECH-Associated Protein 1KRAS protein, humanNF-E2-Related Factor 2PolyaminesProto-Oncogene Proteins p21(ras)

Identifiers

PMID41219185
PMCPMC12606100

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.