Evidence map›Paper›PMID 41219196›Full record

ArticleNature communications2025

Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping.

Matt Udakis, Matthew D B Claydon, Heng Wei Zhu, Elsa C Oakes, Jack R Mellor

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Dendritic Inhibition Terminates Plateau Potentials in CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matt UdakisSchool of Physiology, Pharmacology and Neuroscience, University Walk, University of Bristol, Bristol, UK.
Matthew D B ClaydonSchool of Physiology, Pharmacology and Neuroscience, University Walk, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-3796-6979
Heng Wei ZhuSchool of Physiology, Pharmacology and Neuroscience, University Walk, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0001-7299-7514
Elsa C OakesSchool of Physiology, Pharmacology and Neuroscience, University Walk, University of Bristol, Bristol, UK.ORCID http://orcid.org/0009-0009-1178-8482
Jack R MellorSchool of Physiology, Pharmacology and Neuroscience, University Walk, University of Bristol, Bristol, UK. Jack.Mellor@Bristol.ac.uk.ORCID http://orcid.org/0000-0002-7706-8105

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/N013956/1, BB/N019008/1RCUK | Medical Research Council (MRC) MR/X010910/1Wellcome TrustWellcome Trust (Wellcome) 101029/Z/13/Z, 108899/B/15/Z
6 · The paper itself

Abstract

OLM interneurons selectively target inhibition to the distal dendrites of CA1 pyramidal cells in the hippocampus but the role of this unique morphology in controlling place cell physiology remains a mystery. Here we show in mice that OLM activity prevents associative synaptic plasticity at Schaffer collateral synapses on CA1 pyramidal cells by inhibiting dendritic Ca

Indexed as

CA1 Region, HippocampalHippocampusInterneuronsNeuronal PlasticityPlace CellsAnimalsCalcium SignalingDendritesMaleMiceMice, Inbred C57BLPyramidal CellsSynapses

Identifiers

PMID41219196
PMCPMC12606138

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.