Evidence map›Paper›PMID 41219438›Full record

ArticleDiabetologia2026

Influence of glycaemic management and BMI on cardiac autonomic markers in children with type 1 diabetes: a prospective cohort study.

Ebba Bergdahl, Gun Forsander, Linda Milkovic, Frida Sundberg, Frida Dangardt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ebba BergdahlDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. ebba.bergdahl@gu.se.ORCID http://orcid.org/0000-0002-4649-8401
Gun ForsanderDepartment of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-0266-9651
Linda MilkovicDepartment of Paediatric Clinical Physiology, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Frida SundbergSchool of Medical Sciences, Örebro University, Örebro, Sweden.ORCID http://orcid.org/0000-0002-3681-7173
Frida DangardtDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0003-4632-3916

Funding

Sahlgrenska University Hospitals Research Foundations SU-971860The agreement between the Swedish government and the country councils, the alf agreement. ALFGBG-935282
6 · The paper itself

Abstract

aims/hypothesisOur aim was to examine the presence of subclinical cardiovascular autonomic neuropathy (CAN) in a cohort of children with well-regulated type 1 diabetes by measuring baroreceptor sensitivity (BRS), QT variability index (QTVI) and heart rate variability (HRV).

methodsForty-five children (aged 6-15.99 years) with a type 1 diabetes duration of ≥5 years, and 37 healthy control children were included at baseline; and 28 and 18 children, respectively, were included at 2 year follow-up. Cardiac BRS, QTVI and HRV were measured and anthropometrical data and blood samples were collected from all study participants. Longitudinal HbA

resultsTime in normoglycaemia (TING) increased significantly from 42% to 48% between baseline and 2 year follow-up (p=0.042). No difference in BRS, QTVI or HRV were found between the study groups at baseline or follow-up. Children with type 1 diabetes with a BMI z score ≥1 showed higher QTVI compared with either lean children with diabetes or healthy control children. QTVI correlated with type 1 diabetes duration, longitudinal HbA CONCLUSIONS/

interpretationIn this well-regulated type 1 diabetes cohort we did not find manifest signs of CAN in children with type 1 diabetes. These are promising findings and should motivate further to keep striving for normoglycaemia in paediatric diabetes care. Children with both type 1 diabetes and overweight seem more susceptible to early development of CAN and might benefit from earlier and more intensive preventive targeting.

Indexed as

Autonomic Nervous SystemDiabetes Mellitus, Type 1AdolescentBiomarkersBlood GlucoseBody Mass IndexChildDiabetic NeuropathiesFemaleGlycated HemoglobinGlycemic ControlHeart RateHumansMaleProspective StudiesBiomarkersBlood GlucoseGlycated HemoglobinAutonomic dysfunctionCardiac autonomic neuropathyChildrenPaediatricsType 1 diabetes

Identifiers

PMID41219438
PMCPMC12779695

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.