ArticlePediatric research2025
Early growth restriction disrupts mice intestinal clock and homeostasis without being prevented by lactoferrin.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreterm infants and growth-restricted newborns are highly susceptible to intestinal inflammation and sepsis. We studied the effects of oral supplementation with bovine lactoferrin (bLf) during lactation in postnatal growth-restricted (PNGR) mice on intestinal development and susceptibility to colitis at weaning.
methodsGrowth restriction was induced in FVB/NRj mice from large litters from postnatal day (PN) 4 to 21. bLf (300 mg/kg/d) was administered from PN8 to PN21. Intestinal function was evaluated at PN21 by morphology, RNA sequencing, microbiota composition, and cecal short chain fatty acid levels. At PN22, acute colitis was induced by 3% dextran sulfate sodium (DSS). Colitis severity was assessed at PN29 histologically and RT-qPCR.
resultsPNGR altered the expression of genes related to circadian rhythm in intestines but did not increase susceptibility to DSS-induced acute colitis post weaning. PNGR-induced growth retardation and intestinal immaturity were not improved by bLf supplementation. bLf supplementation affected the microbiota composition in control, but not PNGR pups, and slightly reduced the inflammatory effects of colitis in PNGR.
conclusionPNGR alters intestinal development by affecting the intestinal transcriptome during lactation. bLf supplementation does not prevent growth restriction effects on gut health but could modulate gut microbiota in control pups during this period. IMPACT: Postnatal growth restriction induces changes in the intestinal transcriptome with a disruption of clock-related gene expression. Postnatal growth restriction alters intestinal microbiota composition but does not amplify the response to an inflammatory-induced acute colitis after weaning. Bovine lactoferrin supplementation does not improve an induced growth restriction and its altered intestinal barrier structure. Bovine lactoferrin supplementation may induce positive intestinal microbial changes especially in control mice during lactation.
Identifiers
41219462What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.