Evidence mapPaperPMID 41219536Full record

ArticleEMBO molecular medicine2025

Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome.

Yojet Sharma, Priyanka Bhatia, Gagana Rangappa, Sankhanil Saha, Padinjat Raghu

Abstract read
In one paragraph

Article in EMBO molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mitochondrial structure and function in OCRL depleted cells.Frontiers in cell and developmental biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yojet SharmaNational Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India.ORCID 0000-0002-4755-8066
Priyanka BhatiaNational Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India.ORCID 0000-0003-0912-2672
Gagana RangappaNational Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India.ORCID 0009-0001-9740-5172
Sankhanil SahaNational Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India.
Padinjat RaghuNational Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India. praghu@ncbs.res.in.ORCID 0000-0003-3578-6413

Funding

Department of Atomic Energy, Government of India (DAE) RTI4006Department of Biotechnology, Ministry of Science and Technology, India (DBT) BT/PR17316/MED/31/326/2015Pratiksha Trust RPRohini Nilekani Centre for Brain and Mind RPWellcome TrustWellcome Trust DBT India Alliance (India Alliance) IA/S/14/2/501540
6 · The paper itself

Abstract

Coordination of cellular and physiological development by signaling is required for normal brain structure and function. Mutations in OCRL, a phosphatidylinositol 4,5 bisphosphate [PI(4,5)P

Indexed as

NeurogliaOculocerebrorenal SyndromeReceptors, NotchCalcium-Binding ProteinsCell DifferentiationHumansInduced Pluripotent Stem CellsMembrane ProteinsNeural Stem CellsPhosphoric Monoester HydrolasesSignal TransductionCalcium-Binding ProteinsDLK1 protein, humanMembrane ProteinsOCRL protein, humanPhosphoric Monoester HydrolasesReceptors, NotchBrain OrganoidsDisease ModeliPSC-derived NeuronsLowe SyndromePhosphoinositides

Identifiers

PMID41219536
PMCPMC12686420

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.