Evidence map›Paper›PMID 41219603›Full record

ReviewAdvances in experimental medicine and biology2026

Glucagon-Like Peptide-1: The Role of Calcium in Gut-Glucose Axis.

Astrid-Ines Foamkom, Hosam G Abdelhady, Mohammed S Razzaque

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Astrid-Ines FoamkomDepartment of Medical Education, School of Medicine, University of Texas Rio Grande Valley (UTRGV), Edinburg, TX, USA.
Hosam G AbdelhadyDepartment of Physiology & Pharmacology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX, USA.
Mohammed S RazzaqueDepartment of Medical Education, School of Medicine, University of Texas Rio Grande Valley (UTRGV), Edinburg, TX, USA. mohammed.razzaque@utrgv.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucagon-like peptide-1 (GLP-1) is a key metabolic hormone secreted by intestinal L-cells in response to nutrient ingestion. It plays a central role in regulating glucose homeostasis by enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and suppressing appetite. While glucose, fat, and protein are established stimulators of GLP-1 release, calcium has emerged as a key modulator of this enteroendocrine axis. Recent studies have shown that extracellular calcium, acting through the calcium-sensing receptor (CaSR) and voltage-gated calcium channels, triggers intracellular calcium influx, which is essential for GLP-1 exocytosis from L-cells. This highlights the role of calcium not merely as a dietary mineral but as a signaling ion that links nutrient sensing in the gastrointestinal tract to the hormonal regulation of blood glucose homeostasis. This chapter briefly explains how calcium influences the GLP-1-mediated gut-glucose axis.

Indexed as

Blood GlucoseCalciumEnteroendocrine CellsGastrointestinal TractGlucagon-Like Peptide 1GlucoseAnimalsCalcium SignalingHomeostasisHumansReceptors, Calcium-SensingBlood GlucoseCalciumGlucagon-Like Peptide 1GlucoseReceptors, Calcium-SensingCalciumDiabetes mellitusGastric emptyingGLP-1 receptor agonistsGlucagon-like peptide-1Hypoglycemia

Identifiers

PMID41219603

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.