ArticleJournal of molecular histology2025
The molecular footprint of the serotoninergic system in human glioblastoma cells.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Neurotransmitter-Mediated Signaling in Glioblastoma and Glial Tumors: Biology and Therapeutic Opportunities.Oncology research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Serotonin plays a regulatory role in cancer progression, but its role in glioblastoma growth, the most frequent and aggressive malignant brain tumor, is unclear. The expression and cellular distribution pattern of key components of the serotoninergic system in glioblastoma cells have not been fully characterized. Using transcriptomic analysis of public datasets, we identified subtype-specific expression pattern of serotonin-related genes. The biosynthetic enzymes tryptophan hydroxylase 1 and 2 and the serotonin transporter (SERT/SLC6A4) were enriched in the classical (CL) and proneural (PN) molecular subtypes, whereas monoamine oxidase-A expression was uniformly distributed across all subtypes. Notably, the serotonin receptors HTR1D and HTR7 transcripts were upregulated in ME and CL tumors. Additionally, by using RT-qPCR and immunofluorescence, we observed a differential expression and intracellular distribution pattern of all serotoninergic system elements in human glioblastoma-derived cell lines. Our findings demonstrate the differential expression and cellular localization of the serotoninergic elements in human glioblastomas and suggest their potential participation in their progression.
Indexed as
Identifiers
41219608What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.