Evidence map›Paper›PMID 41219667›Full record

ArticleAAPS PharmSciTech2025

Overcoming Bioavailability Barriers: Optimized Hybrid Nanocarrier System to Amplify Berberine Absorption via Peyer's Patches.

Shubhangi A Thool, Varsha B Pokharkar

Abstract read
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In one paragraph

Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Poly(methyl vinyl ether-Polymers · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shubhangi A ThoolDepartment of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Erandwane, Pune-411038, India.ORCID http://orcid.org/0009-0000-2478-0134
Varsha B PokharkarDepartment of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Erandwane, Pune-411038, India. varsha.pokharkar@bharatividyapeeth.edu.ORCID http://orcid.org/0000-0001-5464-9620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Berberine, an isoquinoline alkaloid, is a compound of interest due to its structural diversity and wide range of biological activities; however, its pharmacological effects are significantly limited by poor intestinal absorption. In this study, a novel formulation approach was employed to improve the bioavailability of berberine by formulating lipid-polymer hybrid nanoparticles (BER-LPHN) using a modified nanoprecipitation method. The formulation was optimized using a 3

Indexed as

BerberineDrug CarriersNanoparticlesPeyer's PatchesAdministration, OralAnimalsBiological AvailabilityChemistry, PharmaceuticalDrug LiberationIntestinal AbsorptionLipidsMaleMiceParticle SizePolymersBerberineDrug CarriersLipidsPolymersbioavailability enhancementdesign of experimentsionic interactionlipid-polymer hybrid nanoparticlespeyer’s patch uptake

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.