ArticleBasic and clinical andrology2025
Exploring the causal associations between obesity indicators and male reproductive diseases: new evidence from Mendelian randomization.
Article in Basic and clinical andrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe objective of this study was to investigate potential causal associations between indicators of obesity and male reproductive disorders using Mendelian randomization (MR) analysis.
methodsBased on summary data from the GWAS, we conducted MR analyses. Univariable MR analysis was performed to estimate the association between three obesity indicators and five male reproductive diseases. Multivariable MR analysis was conducted to account for pleiotropy observed in univariable MR analysis by including a set of covariates.
resultsUnivariable MR analysis revealed suggestive associations between waist-to-hip ratio (WHR) and testicular dysfunction (OR = 0.32, 95% Cl: 0.11-0.99, P
conclusionOur two-sample MR analysis suggests generalized obesity in was suggestively associated with the increased risk of erectile dysfunction, while central obesity obesity is associated with an decreased risk of testicular dysfunction.
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