ReviewStem cell research & therapy2025
Mechanism of mesenchymal stem cells in treating diabetic kidney disease.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic kidney disease (DKD) is a serious microvascular complication of diabetes, with symptoms of progressive kidney dysfunction, proteinuria, and fibrosis, ultimately causing end-stage renal disease. Mesenchymal stem cells (MSCs) represent a promising therapeutic approach for DKD, primarily through their paracrine effects. In this review, we concluded the mechanism of MSCs in treating DKD, including the inhibition of inflammation, fibrosis, oxidative stress, and modulate vascular endothelial growth factor (VEGF). Additionally, we discuss strategies to enhance MSC efficacy, such as preconditioning, genetic engineering, and combination therapies with pharmacological agents. Furthermore, we provide an overview of completed clinical trials assessing the effectiveness and safety of MSCs transplantation in DKD patients. The purpose of this review is to highlight the MSCs' potential as an innovative treatment for DKD and to guide future research toward optimizing their therapeutic applications, ultimately improving DKD patients' quality of life.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.