ArticleThe Journal of physiology2026
Generalised Hodgkin-Huxley model captures human P2X and AMPA receptor currents.
Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ionotropic receptors are transmembrane ion channels that play central roles in regulating synaptic transmission in the nervous system and cellular activity underlying immune responses. However, a unified mathematical model capturing their dynamics remains elusive. In this paper a generalised Hodgkin-Huxley (gHH) model is introduced, which seamlessly represents different activation, inactivation and recovery dynamics of the entire human P2X receptor family and the human AMPA-type glutamate receptor. The model incorporates two activation gates (m
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