ArticleJournal of gastrointestinal oncology2025
Trends and incidence of stomach cancer in middle-aged and elderly populations: a global burden of disease analysis.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Transcatheter arterial embolization with N-butyl cyanoacrylate versus gelatin sponge particles for gastric cancer-related upper gastrointestinal bleeding: a comparison of efficacy and safety.Journal of gastrointestinal oncology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Stomach cancer remains a leading cause of cancer deaths in middle-aged and elderly populations. This study aimed to examine global trends in incidence among individuals aged 50-74 years and to explore disparities by age, sex, and region using Global Burden of Disease (GBD) data. Methods: Data on stomach cancer incidence were extracted from the GBD 2021 database. We analyzed incidence rates for individuals aged 50-74 years, stratified by age, sex, and geographic region. Trends from 1990 to 2021 were evaluated using the Estimated Annual Percentage Change (EAPC) based on log-linear regression models. Pearson correlation was used to examine associations between incidence trends and the Socio-Demographic Index (SDI). Data standardization was based on the GBD world standard population. Results: From 1990 to 2021, the number of stomach cancer cases among individuals aged 50-74 years increased by 17.32%, while the incidence rates declined from 80.67 to 44.18 per 100,000 (EAPC: -2.15). Males consistently exhibited higher incidence rates than females. The decline was less pronounced in older age groups, particularly those aged 65-74 years, where the number of cases continued to rise, reflecting population aging and cumulative risk exposure. High-SDI regions experienced the largest reductions (e.g., East Asia: EAPC -2.02), whereas progress was limited in low-SDI areas such as Southern and Eastern Sub-Saharan Africa. A strong negative correlation between SDI and incidence trends (ρ=-0.491) underscored the influence of socioeconomic development on disease reduction. Conclusions: This study reveals marked regional and demographic disparities in stomach cancer trends among aging populations. Socioeconomic development plays a central role in reducing incidence. To reduce global health inequities, efforts should prioritize equitable access to screening and treatment, culturally tailored prevention programs, and investment in healthcare infrastructure in low-SDI regions.
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