ArticleJournal of gastrointestinal oncology2025
Preoperative prediction of tumor budding in colorectal cancer based on quantitative parameters of dual-layer detector spectral computed tomography: a preliminary study.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Prognostic and therapeutic significance of microscopic tumor focus in combined hepatocellular-cholangiocarcinoma: a multicenter pathological study.Journal of gastrointestinal oncology · 2026Article
- Review
- Spectral CT iodine quantification for peritoneal metastasis burden and resectability prediction in ovarian cancer: a retrospective cohort study.Frontiers in oncology · 2026Article
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7 authors.
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Abstract
Background: Tumor budding (TB) is an autonomous risk factor indicative of the invasiveness and prognosis of colorectal cancer (CRC). Dual-layer spectral detector computed tomography (SDCT) is a novel energy-resolved imaging technology that enables multiparametric tissue characterization through quantitative spectral analysis. Nevertheless, the efficacy of quantitative measures derived from SDCT in differentiating the TB grade of CRC remains ambiguous. This research aims to evaluate the efficacy of SDCT in preoperatively predicting TB grade in CRC. Methods: This retrospective study enrolled 74 consecutive CRC patients who underwent surgical resection with confirmed TB grade at the First Hospital of Lanzhou University between July 2023 and July 2024. All patients received whole-abdomen spectral computed tomography (CT) scans within one week preoperatively. Based on postoperative pathology, patients were stratified into low-grade TB (Group A, Bd1) and high-grade TB (Group B, Bd2 + Bd3) groups. Using the IntelliSpace Portal workstation, radiologists manually delineated regions of interest (ROIs) on axial images to measure spectral CT quantitative parameters in both arterial and venous phases, encompassing CT values at 40 and 120 keV (CT Results: The research included a total of 74 individuals with CRC (mean age: 61.16±13.08 years; male: 36, female: 38). Compared with the low-grade TB group, the high-grade TB group showed significantly higher proportions of both high-grade tumors (P=0.001) and elevated Ki-67 expression (P=0.009), along with a significantly increased likelihood of lymphovascular invasion (P=0.005). The CT Conclusions: Quantitative parameters of spectral CT may be associated with TB grade in CRC, and their potential value in preoperatively predicting different TB grades could be of great significance for guiding clinical treatment selection and prognostic evaluation.
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