ArticleJournal of gastrointestinal oncology2025
Oral microbial alterations by smoking and metabolic factors in esophageal squamous cell carcinoma.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Prognostic value of left gastric artery lymph node metastasis in patients with thoracic esophageal squamous cell carcinoma: a retrospective cohort study.Journal of thoracic disease · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: It is important to understand how clinical factors affect microbial profiles, but few studies have evaluated these associations in patients with esophageal squamous cell carcinoma (ESCC). This study aimed to analyze differences in the oral microbiome between patients with ESCC and healthy controls, with subgroup analyses stratified by clinical and metabolic factors. Methods: From December 2021 to May 2023, oral swab samples and clinical data were collected from participants at five tertiary medical centers. Clinical data included age, sex, body mass index (BMI), smoking history, metabolic profiles such as cholesterol, triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein, and endoscopic findings. Sequencing and taxa abundance analyses were performed to compare oral microbiota between patients with ESCC and controls. Subgroup analyses were conducted to explore the impact of clinical factors on microbial community composition and diversity. Results: No significant differences in α- or β-diversity were observed between ESCC patients (n=21) and controls (n=20). However, subgroup analyses revealed distinct microbial patterns. Conclusions: The oral microorganisms
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