Evidence map›Paper›PMID 41220804›Full record

ReviewFrontiers in bioengineering and biotechnology2025

Clinical applications of extracellular vesicles: recent advances and emerging trends.

Yitan Zou, Yaping Zhou, Guangyao Li, Yuchao Dong, Shi Hu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yitan Zou *Department of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Yaping Zhou *Department of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Guangyao Li *Department of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Yuchao DongDepartment of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China.
Shi HuDepartment of Biomedical Engineering, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication and promising theranostic agents in medicine. These naturally-derived nanoparticles possess unique advantages including stable physicochemical properties, low immunogenicity, and inherent biocompatibility. In recent years, increasing attention has been directed toward clinical investigations. Driven by these clinical studies, several EV-based diagnostic and therapeutic products have emerged. In this review, we aimed to highlight and discuss the completed and emerging clinical investigations of EV-based strategies, critically elucidate persistent technical and translational hurdles impeding clinical implementation, and propose strategic directions to accelerate realization of the transformative potential inherent in EV-mediated precision medicine.

Indexed as

cancer theranosticsclinical applicationclinical trialdrug deliveryextracellular vesiclesMSC-derivedEVs

Identifiers

PMID41220804
PMCPMC12598036

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.