Evidence map›Paper›PMID 41221213›Full record

ArticleFrontiers in veterinary science2025

Evaluation of the antimicrobial and cytotoxic activity of nerolidol encapsulated in a nanoliposome system.

Nicolò Mezzasalma, Costanza Spadini, Federico Righi, Marica Simoni, Gaetano Lamberti, Anna Angela Barba, Dante Greco, Alessia Merelli, Lorenzo Bosio, Alessandro Cupola and 3 more

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Natural Products AgainstMicroorganisms · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nicolò Mezzasalma *Department of Veterinary Science, University of Parma, Parma, Italy.
Costanza Spadini *Department of Veterinary Science, University of Parma, Parma, Italy.
Federico RighiDepartment of Veterinary Science, University of Parma, Parma, Italy.
Marica SimoniDepartment of Veterinary Science, University of Parma, Parma, Italy.
Gaetano LambertiDepartment of Industrial Engineering, University of Salerno, Fisciano, Italy.
Anna Angela BarbaEnhanced Systems and Technology Srl, Avellino, Italy.
Dante GrecoFarmer Spa R&D Department, Mantova, Italy.
Alessia MerelliFarmer Spa R&D Department, Mantova, Italy.
Lorenzo BosioFarmer Spa R&D Department, Mantova, Italy.
Alessandro CupolaDepartment of Veterinary Science, University of Parma, Parma, Italy.
Emiliana SchianoDepartment of Veterinary Science, University of Parma, Parma, Italy.
Simone TaddeiDepartment of Veterinary Science, University of Parma, Parma, Italy.
Clotilde Silvia CabassiDepartment of Veterinary Science, University of Parma, Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-derived compounds have emerged as potential alternatives to traditional antimicrobials in livestock; however, their application may be limited by degradation in the gastrointestinal tract. Nanoliposome encapsulation offers a strategy to overcome these limitations. In this study, we investigated the effects of nerolidol encapsulation, by evaluating the antimicrobial activity of free-nerolidol (NER), nerolidol-loaded nanoliposomes (LN), and unloaded nanoliposomes (UN) (Lipobox™) using a Time-Kill assay. The cytotoxicity of these formulations was assessed through MTT assay on swine and bovine cell lines. NER was effective against MRSA,

Indexed as

alternative antimicrobialsanimal nutritionliposomelivestockplant feed additivestime-kill assay

Identifiers

PMID41221213
PMCPMC12597719

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.