Evidence map›Paper›PMID 41221328›Full record

ArticleJournal of oral microbiology2025

Inhibition of BTK and SYK attenuates

Alicja Plonczynska, Aureliusz Schuster, Dominika M Drapala, Tomasz Kaczmarzyk, Magdalena Nowak, Jan Potempa, Aleksander M Grabiec, Maja Sochalska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alicja PlonczynskaDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID https://orcid.org/0000-0002-4913-315X
Aureliusz SchusterDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID https://orcid.org/0000-0002-3658-3733
Dominika M DrapalaDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID https://orcid.org/0009-0006-1825-7172
Tomasz KaczmarzykChair of Oral Surgery, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.ORCID https://orcid.org/0000-0003-3024-9926
Magdalena NowakDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Jan PotempaDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Aleksander M GrabiecDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID https://orcid.org/0000-0001-9472-850X
Maja SochalskaDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Periodontitisis a chronic inflammatory disease of the oral cavity, primarily driven by periodontopathogens such as Objective: We investigated the therapeutic potential of BTK and SYK inhibitors on the pathological processes induced by two Design: hMDM and hGF were infected with Results: Ibrutinib and R406 suppressed Conclusions: The pharmacological inhibition of BTK or SYK mitigates the pyroptotic pathway in hMDMs and exerts a broad anti-inflammatory effect in both hMDMs and hGFs. These results highlight the anti-inflammatory potential of BTK and SYK inhibitors for the treatment of periodontal disease.

Indexed as

fibroblastskinasemacrophagesperiodontitisPorphyromonas gingivalispyroptosis

Identifiers

PMID41221328
PMCPMC12599364

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.