Evidence map›Paper›PMID 41221981›Full record

ArticleOrthodontics & craniofacial research2026

The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement.

Lisa Latzko, Gerald Degenhart, Michael J Blumer, Reinhard Gruber, Johannes Haybäck, Claudia Manzl, Adriano G Crismani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthodontics & craniofacial research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lisa LatzkoUniversity Hospital for Orthodontics, Department of Dental and Oral Medicine and Cranio-Maxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0009-0002-7523-0268
Gerald DegenhartDepartment of Radiology, Core Facility MicroCT, Medical University Innsbruck, Innsbruck, Austria.
Michael J BlumerInstitute of Clinical and Functional Anatomy, Medical University of Innsbruck, Innsbruck, Austria.
Reinhard GruberDepartment of Oral Biology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0001-5400-9009
Johannes HaybäckTyrolpath Obrist Brunhuber GmbH, Zams, Austria.
Claudia ManzlInstitute of Pathology, Neuropathology and Molecular Pathology, Medical University Innsbruck, Innsbruck, Austria.
Adriano G CrismaniUniversity Hospital for Orthodontics, Department of Dental and Oral Medicine and Cranio-Maxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria.

Funding

Tiroler Wissenschaftsförderung F.45069/8-2022
6 · The paper itself

Abstract

objectiveThe NLRP3 inflammasome is a damage sensor driving pyroptotic cell death during orthodontic tooth movement (OTM). Recent studies have revealed impaired one-week OTM in mice lacking NLRP3. However, the relevance of NLRP3 during long-term OTM remains unknown. MATERIALS AND

methodsOTM was analysed after 7, 14 and 21 days of force application in mice lacking NLRP3 (NLRP3

resultsWe show here that after 2 weeks of force application, OTM was delayed in mice lacking NLRP3 compared to WT mice. Interestingly, OTM regained speed in NLRP3

conclusionThe results of this study suggest that NLRP3 is relevant during the early but not later stages of OTM.

Indexed as

InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinTooth Movement TechniquesAlveolar Bone LossAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutOsteoclastsTartrate-Resistant Acid PhosphataseX-Ray MicrotomographyInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseTartrate-Resistant Acid Phosphatasemicro‐CTNLRP3 Inflammasomeorthodontic tooth movementTRAP

Identifiers

PMID41221981
PMCPMC12779247

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.