Evidence mapPaperPMID 41222108Full record

ReviewGenesis (New York, N.Y. : 2000)2025

ATRX: From Chromatin Remodeling to Disease.

Mauro Magaña-Acosta, Viviana Valadez-Graham

Abstract readReview
In one paragraph

Review in Genesis (New York, N.Y. : 2000), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mauro Magaña-AcostaDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
Viviana Valadez-GrahamDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.ORCID 0000-0002-2556-7375

Funding

Programa de apoyo a Proyectos de Investigación e Innovación Tecnológica PAPIIT, DGAPA-UNAM IN203521Programa de apoyo a Proyectos de Investigación e Innovación Tecnológica PAPIIT, DGAPA-UNAM IN218425SECIHTI 925658Secretaria de Ciencias, Humanidades, Tecnología e Innovación, SECIHTI (former CONACyT) A1-S-8239Universidad Nacional Autónoma de México
6 · The paper itself

Abstract

Chromatin remodeling proteins are evolutionarily conserved factors involved in a wide range of biological processes. In this review, we describe ATRX, a chromatin remodeling protein belonging to the SWI/SNF2 family. Its association with different protein complexes, and its roles in embryonic development, sexual differentiation, as well as retinal and brain function. We further discuss and integrate current findings on pathologies associated with ATRX dysfunction such as ATR-X syndrome, focusing on its etiology, clinical features, and potential diagnostic tools. Finally, we propose that ATRX may contribute to the progression of certain neurodegenerative diseases and review recent literature supporting this hypothesis.

Indexed as

Chromatin Assembly and DisassemblyDNA HelicasesNuclear ProteinsX-Linked Intellectual Disabilityalpha-ThalassemiaAnimalsHumansNeurodegenerative DiseasesX-linked Nuclear ProteinATRX protein, humanDNA HelicasesNuclear ProteinsX-linked Nuclear ProteinATRXATR‐X syndromechromatin remodelingdisease

Identifiers

PMID41222108
PMCPMC12607251

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.