Evidence map›Paper›PMID 41222145›Full record

ArticlemBio2025

A synthetic gut microbiota provides an understanding of the maintenance and functional impact of phage.

Heejung Koo, Kerim Heber, Shuchang Tian, Shane T Connolly, Fuhua Hao, Jingcheng Zhao, Bethany Swencki-Underwood, Andrew D Patterson, Guy E Townsend, Jordan E Bisanz

Abstract readLegislation
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Research square · 2026
    Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heejung Koo *Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0009-3715-9713
Kerim Heber *Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0008-0443-294X
Shuchang TianDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0008-7920-4693
Shane T ConnollyDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0000-7483-6263
Fuhua HaoDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-0865-5269
Jingcheng ZhaoDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0004-0447-6652
Bethany Swencki-UnderwoodDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Andrew D PattersonDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-2073-0070
Guy E TownsendOne Health Microbiome Center, Huck Life Sciences Institute, University Park, Pennsylvania, USA.ORCID 0000-0002-8231-3769
Jordan E BisanzDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-8649-1706

Funding

Harnessing the gut microbiome to detect and quantify glycansR01GM147178 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI TOWNSEND, GUY EDMUND · 2022 to 2025
$1.8M
Decoding Microbial Diversity in the Human Gut MicrobiomeR35GM151045 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Jordan Adam Bisanz · 2023 to 2026
$1.5M
Biotechnological and Integrative Opportunities in Microbiome Sciences (BIOMS)T32GM156692 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI SETH R BORDENSTEIN, Jasna Kovac · 2025 to 2026
$1.1M
Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training ProgramT32DK120509 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW, PERDEW, GARY H. · 2020 to 2024
$781k
Diet-microbe interactions modulating host energy balanceR00AI147165 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI BISANZ, JORDAN ADAM · 2021 to 2022
$498k
NIAID NIH HHS R00 AI147165NIDDK NIH HHS T32 DK120509NIGMS NIH HHS R01 GM147178NIGMS NIH HHS R35 GM151045NIGMS NIH HHS T32 GM156692
6 · The paper itself

Abstract

Phages are under intense study as therapeutics and mediators of microbial community behavior; however, tractable models are needed to study phages in the context of the mammalian gut. To address this gap, we isolated phages against members of a synthetic gut microbial community (sFMT), identifying the IMPORTANCE: Phages are key members of the gut microbiome, but the understanding of their biological significance for host health lags behind their bacterial hosts. In this study, we demonstrate the use of a phage-infection model using defined, synthetic microbial communities that colonize the intestinal tract of mice. We uncovered that spontaneous inversions in the genome of

Indexed as

BacteriophagesBacteroidesGastrointestinal MicrobiomeAnimalsGerm-Free LifeMicebacteriophagesgnotobioticsgut microbiomemetagenomicssynthetic communities

Identifiers

PMID41222145
PMCPMC12691588

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.