ReviewAnnals of biomedical engineering2026
Bioengineered Teeth and Regenerative Strategies: Advances in Tissue Engineering and Stem Cell Applications.
Review in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Extending the Discussion on Bioengineered Tooth Regeneration: Translational Considerations for Clinical Implementation.Annals of biomedical engineering · 2026Article
- The light at the other end of the tunnel: heeding two decades of regeneration research to reclaim natural tooth preservation.Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tooth and endodontic disease pose important challenges, and traditional therapies are dependent upon mechanical restoration rather than biological regeneration. Progress in tissue engineering, biofabrication, and biomaterials science is increasingly supporting regenerative endodontics and bioengineered tooth construction through the use of stem cell-based methods, functionalized scaffolds, and 3D bioprinting technologies. This article summarizes advances in bioengineered dental tissue, emphasizing scaffold design, regulation of induced pluripotent stem cell and dental pulp stem cell differentiation, and solutions for vascularization and innervation. Such important biomaterials as PLGA, alginate, bioactive ceramics, and nanomaterials have been evaluated for their ability to regulate cell behavior and tissue integration. The new role of artificial intelligence in scaffold design and growth factor delivery is presented. There are persisting challenges of mimicking native tooth complexity, obtaining functional vasculature, and satisfying regulatory requirements for bioengineered tooth models. Future directions are expected to emphasize novel biofabrication technologies, the use of high-throughput screening for optimizing biomaterials, and the development of scalable production processes. This article provides a roadmap for translating bioengineered dental constructs from preclinical models to clinical-scale regenerative solutions, with implications for broader tissue engineering fields beyond dentistry.
Indexed as
Identifiers
41222821What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.