ArticleMolecular genetics and genomics : MGG2025
Reliable estimates of Japanese encephalitis virus evolutionary rate supported by a formal test of temporal signal.
Article in Molecular genetics and genomics : MGG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The single-stranded RNA viruses exhibit stupendously high evolutionary rate spanned several orders of magnitude. The accurate and reliable estimates of the virus evolutionary rate are of importance for the robust interpretation of outbreak investigations and are critical for understanding short-term virus transmission patterns. In the previous studies, the substitution rate of the Japanese encephalitis virus (JEV) and time to the most recent common ancestor (MRCA) were reported, however, the estimates are substantially different between some of the studies. Importantly, temporal signal in data was not evaluated by a formal test. The purpose of our study is to estimate the substitution rate and the age of the JEV common clade (GI-GV) and of two JEV genotypes (GI and GIII) supported by a formal Bayesian analysis of temporal signal in the open reading frame (ORF) nucleotide data. Additionally, we assessed temporal signal in the data from the previous work to explain the observed discrepancy between the reported JEV evolutionary rate estimates. Results showed that the mean substitution rate of the JEV GI-GV was 2.41 × 10
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