Evidence map›Paper›PMID 41222881›Full record

SynthesisJournal of endocrinological investigation2025

Potential diagnostic value of microRNAs in vascular complications of diabetes: A systematic review and meta-analysis.

Yijue Wang, Tengyue Hu, Wenling Gu, Boyu Cai, Min Lei, Yingyu Luo, Changhai Liu, Nannan Zhang

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. snoRNAs: New players in CKD biomarkers.Molecular therapy. Nucleic acids · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yijue Wang *National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, No. 17, South Renmin Road, Wuhou, Chengdu, 610041, Sichuan, China.
Tengyue Hu *Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, China.
Wenling GuCollege of Life Sciences, Sichuan University, Chengdu, 610041, Sichuan, China.
Boyu CaiCollege of Life Sciences, Sichuan University, Chengdu, 610041, Sichuan, China.
Min LeiNational Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, No. 17, South Renmin Road, Wuhou, Chengdu, 610041, Sichuan, China.
Yingyu LuoNational Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, No. 17, South Renmin Road, Wuhou, Chengdu, 610041, Sichuan, China.
Changhai LiuCenter of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, 610041, China.
Nannan ZhangNational Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, No. 17, South Renmin Road, Wuhou, Chengdu, 610041, Sichuan, China. nannan7687@scu.edu.cn.

Funding

General Project of Natural Science Foundation Project of Sichuan 2024NSFSC0599the Key Research and Development Program of Chengdu 2023-YF09-00052-SNthe Young Teachers' Science and Technology Innovation Capability Enhancement Project of Sichuan University 2024SCUQJTX037
6 · The paper itself

Abstract

introductionVascular complications of diabetes (VCDs), categorized into microvascular and macrovascular types, lower the quality of life among individuals with diabetes mellitus (DM). microRNAs (miRNAs, miR) are being explored as biomarkers for early identification of VCDs. Numerous studies have investigated alterations in miRNAs associated with VCDs, primarily focusing on microvascular complications such as diabetic nephropathy (DN), diabetic retinopathy (DR), and diabetic foot ulcer (DFU).

methodsWe conducted a systematic review based on PubMed, Embase, and the Cochrane Central Register of Controlled Trials to identify studies on miRNAs in VCDs. We reported miRNA qPCR expression profiles and diagnostic accuracy in VCDs.

resultsA total of 281 articles were included in the systematic review, 156 articles were included in the meta-analysis on qPCR data, and eight studies were included in the diagnostic meta-analysis. miR-126-3p was the most frequently reported miRNA in VCDs. miR-192-5p distinguished DN from healthy controls with an area under the curve (AUC) of 0.96 (95% CI: 0.93-1.00) and distinguished DN from DM with an AUC of 0.79 (95% CI: 0.67-0.92). miR-221-3p distinguished DR from DM with an AUC of 0.83 (95% CI: 0.69-0.96).

conclusionsCirculating miR-126-3p was the most promising biomarker for VCDs. More studies are needed to validate the diagnostic accuracy of miR-192 and miR-221 in VCDs. REGISTRATION: PROSPERO registration number CRD42024603412.

Indexed as

Diabetic AngiopathiesMicroRNAsBiomarkersDiabetic NephropathiesDiabetic RetinopathyHumansBiomarkersMicroRNAsDiabetic nephropathyDiabetic retinopathyMicroRNASystematic review with meta-analysisVascular complication of diabetes

Identifiers

PMID41222881

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.