Evidence map›Paper›PMID 41223521›Full record

ArticlePlacenta2025

Association between MRI-derived early second trimester placental physiology and birth weight percentiles in pregnancies without ischemic placenta disease (IPD).

Raymi O Ramirez, Jennifer J Kim, Precious Ann Fortes, Carla Janzen, Peggy Sullivan, Sherin U Devaskar, Kyunghyun Sung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Raymi O RamirezPhysics and Biology in Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: raymiramirez@mednet.ucla.edu.
Jennifer J KimDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Precious Ann FortesDepartment of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Carla JanzenUniversity of Obstertrics & Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Peggy SullivanDepartment of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Sherin U DevaskarDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Kyunghyun SungPhysics and Biology in Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Funding

Imaging Innovations for Placental Assessment in Response to Environmental PollutionU01HD087221 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U, JANZEN, CARLA · 2015 to 2015
$4.3M
Electrochemical Liquid Biopsy Assessing Placental HealthR01HD100015 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U, WEI, FANG · 2019 to 2023
$3.2M
Biomarkers and Genes Associated with Placental Development and Function in Response to Environmental PollutionR01HD089714 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U · 2016 to 2020
$3.2M
NICHD NIH HHS R01 HD089714NICHD NIH HHS R01 HD100015NICHD NIH HHS U01 HD087221
6 · The paper itself

Abstract

introductionThis study investigated whether placental structure and function, measured using multiparametric MRI (mpMRI) in early second trimester, are associated with birth weight percentiles. We focused on pregnancies without ischemic placental disease (IPD), excluding cases with preeclampsia, fetal growth restriction (FGR), small for gestational age (SGA), or placental abruption. Clinical and pathological moderators were also examined.

methodsIn this prospective single-center cohort, 199 participants were recruited between 2017 and 2019. Placental MRI was performed at two gestational age (GA) windows: 14-16 weeks (w) and 19-24w. Placental volume, perfusion, and oxygenation were quantified and standardized to 16w for the first imaging timepoint and 20w for the second imaging timepoint. After excluding IPD cases, linear mixed-effects models were used to explore retrospective associations between MRI metrics and birth weight percentiles, adjusting for clinical and histopathological variables.

resultsEarly second trimester mpMRI showed significant associations between placental volume (positive association) and perfusion (negative association) as early as 16w GA to birthweight percentiles (p < 0.05). The nonlinear three-way interaction between the change of mpMRI parameters between 16w and 20w GA (Δ w GA) was consistently positively associated to birth weight percentiles regardless of clinical and pathological factors (p < 0.05). DISCUSSION: Early second trimester mpMRI markers (volume and perfusion) at 16w and 20w GA are associated with birth weight outcomes, suggesting utility in early pregnancy monitoring. The three-way interaction between the mpMRI markers may serve as a composite marker for identifying variation in fetal growth trajectories.

Indexed as

Birth WeightPlacentaPlacenta DiseasesPregnancy Trimester, SecondAdultFemaleHumansInfant, NewbornMagnetic Resonance ImagingMultiparametric Magnetic Resonance ImagingPregnancyProspective StudiesBirth weightBMIFetal sexHypoxic scoreImagingPlacentaRegression

Identifiers

PMID41223521
PMCPMC12863204

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.