Evidence map›Paper›PMID 41224270›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Cerebellar-onset Progressive Multifocal Leukoencephalopathy (PML) Associated with Hepatitis B-related Liver Cirrhosis.

Kota Sato, Akiko Saito, Takeshi Miyazaki, Kazuo Nakamichi, Kenta Takahashi, Harutaka Katano, Tadaki Suzuki, Yuka Terasawa

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kota SatoDepartment of Neurology, Brain Attack Center Ota Memorial Hospital, Japan.
Akiko SaitoDepartment of Neurology, Brain Attack Center Ota Memorial Hospital, Japan.
Takeshi MiyazakiDepartment of Neurosurgery, Brain Attack Center Ota Memorial Hospital, Japan.
Kazuo NakamichiDepartment of Virology 1, National Institute of Infectious Diseases, Japan Institute for Health Security, Japan.
Kenta TakahashiDepartment of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security, Japan.
Harutaka KatanoDepartment of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security, Japan.
Tadaki SuzukiDepartment of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security, Japan.
Yuka TerasawaDepartment of Neurology, Brain Attack Center Ota Memorial Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a case of progressive multifocal leukoencephalopathy (PML) in a woman in her 70s with hepatitis B-related liver cirrhosis. She presented with cerebellar onset symptoms, including ataxia and dysarthria. The diagnosis was delayed despite the initial magnetic resonance imaging (MRI) findings of an asymmetric cerebellar white matter lesion. PML was ultimately diagnosed based on a re-evaluation of a brain biopsy specimen and a retrospective JC virus (JCV) PCR analysis of the cerebrospinal fluid. Treatment with mefloquine and mirtazapine resulted in viral clearance from the cerebrospinal fluid (CSF) and clinical stabilization. This case highlights that crescent-shaped cerebellar lesions should raise suspicion of PML, even in patients without severe immunodeficiency.

Indexed as

Hepatitis BLeukoencephalopathy, Progressive MultifocalLiver CirrhosisAgedFemaleHumansJC VirusMagnetic Resonance ImagingMefloquineMianserinMirtazapineMefloquineMianserinMirtazapinecrescent-shaped cerebellar lesionhepatitis B virus (HBV)JC virus (JCV)liver cirrhosisprogressive multifocal leukoencephalopathy (PML)

Identifiers

PMID41224270
PMCPMC13349473

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.