Evidence map›Paper›PMID 41224351›Full record

ArticleSaudi medical journal2025

Comparative analysis of autophagy and apoptosis pathways in viral and alcoholic cirrhosis: An immunohistochemical study.

Gunnur Demircan, Selimcan Berk, Doga Karayilan, Berkay T Ozgur, Sema Ketenci, Ipek Elbegi, Vildan Karpuz, Melike Yavuz, Ahmet Midi, Demet Akin

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gunnur DemircanFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.ORCID https://orcid.org/0000-0001-7355-9065
Selimcan BerkFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.
Doga KarayilanFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.
Berkay T OzgurFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.
Sema KetenciFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.
Ipek ElbegiFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.
Vildan KarpuzFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.
Melike YavuzFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.
Ahmet MidiFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.
Demet AkinFrom the Department of Medical Biology & Genetics (Demircan) and from the Department of Pathology (Elbegi, Karpuz), Faculty of Medicine, Demiroglu Bilim University; from the Department of Pharmacology (Berk, Karayilan, Ozgur) and from the Department of Public Health (Yavuz), Faculty of Medicine, Bahcesehir University; from the Department of Medical Pharmacology (Ketenci), Faculty of Medicine, İstinye University; from the Department of Pathology (Midi), Faculty of Medicine, Altınbaş University; from the Department of Medical Pharmacology (Akin), Faculty of Medicine, Uskudar University, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study the different cellular death mechanisms between viral cirrhosis and alcoholic cirrhosis. The research investigated autophagy and apoptosis mechanisms in hepatitis B virus (HBV), hepatitis C virus (HCV) and alcohol-induced cirrhosis.

methodsThe research team analyzed biopsy samples from the liver which were obtained at Florence Nightingale Hospitals, Istanbul, Turkey. The experimental protocols were performed between February 2021 and February 2023. The study included 19 HBV, 15 HCV, 13 alcohol-related cirrhosis patients and 6 normal liver tissues. Beclin-1, Caspase-3, Bcl-2 and LC3 expressions were evaluated by immunohistochemistry.

resultsStaining intensity as well as extent underwent evaluation through H-score methodology. The expression levels of Beclin-1 (control: 0.7±0.3, HBV: 6.0±1.4, HCV: 5.1±1.3, alcohol: 4.8±1.2), caspase-3 (control: 0.4±0.2, HBV: 6.0±1.4, HCV: 5.1±1.2, alcohol: 5.5±1.3) and Bcl-2 (control: 0.3±0.2, HBV: 5.5±1.2, HCV: 4.8±1.1, alcohol: 4.6±1.1) were significantly higher than those of the control group (

conclusionOur findings suggest that both autophagic and apoptotic pathways are active in the pathogenesis of cirrhosis. Similar cell death mechanisms were found to be involved in viral and alcoholic cirrhosis, but these pathways were more prominently activated in viral cirrhosis.

Indexed as

ApoptosisAutophagyHepatitis BHepatitis CLiver CirrhosisLiver Cirrhosis, AlcoholicAdultBeclin-1Caspase 3FemaleHumansImmunohistochemistryMaleMicrotubule-Associated ProteinsMiddle AgedProto-Oncogene Proteins c-bcl-2BCL2 protein, humanBeclin-1BECN1 protein, humanCASP3 protein, humanCaspase 3MAP1LC3A protein, humanMicrotubule-Associated ProteinsProto-Oncogene Proteins c-bcl-2acute-on-chronicliver failureapoptosis in liver diseaseautophagymechanismscirrhosispathogenesisimmunohistochemistry in hepatology

Identifiers

PMID41224351
PMCPMC12625672

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