Evidence map›Paper›PMID 41224440›Full record

ReviewHematology/oncology clinics of North America2026

Contemporary Approaches to Adrenocortical Carcinoma.

Alexa J Hughes, Alexandria D McDow, Hadley E Ritter, Anthony D Yang

Abstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexa J HughesDepartment of Surgery, Surgical Outcomes and Quality Improvement Center (SOQIC), Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall, Indianapolis, IN, USA.
Alexandria D McDowDivision of Surgical Oncology, Department of Surgery, Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall, Indianapolis, IN, USA.
Hadley E RitterDivision of Surgical Oncology, Department of Surgery, Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall, Indianapolis, IN, USA.
Anthony D YangDepartment of Surgery, Surgical Outcomes and Quality Improvement Center (SOQIC), Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall, Indianapolis, IN, USA; Division of Surgical Oncology, Department of Surgery, Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall, Indianapolis, IN, USA. Electronic address: Yangad@iu.edu.

Funding

Surgical Oncology Research Training at Indiana (SORTI)T32CA282070 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI KARL Y BILIMORIA, Harikrishna Nakshatri · 2024 to 2026
$1.5M
NCI NIH HHS T32 CA282070
6 · The paper itself

Abstract

Adrenocortical carcinoma is a rare, aggressive cancer with a poor prognosis. Management of early-stage disease relies on surgical resection, which remains the only potentially curative therapy. Open surgery remains the standard of care, with minimally invasive approaches being appropriate in cases with smaller tumors and no evidence of local invasion. Advanced disease traditionally relies on mitotane-based chemotherapies to control disease progression. Clinical trials evaluating the potential efficacy of immunotherapy, checkpoint inhibitors, and tyrosine kinase inhibitors are ongoing but have yet to yield results that impact guideline-based therapies. Other therapies, such as radiation, are commonly used for recurrent or metastatic disease.

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical CarcinomaHumansImmunotherapyAdrenalectomyAdrenocortical carcinomaChemotherapyTargeted therapy

Identifiers

PMID41224440
PMCPMC13371745

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.